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Design, Synthesis and Biological Evaluation of Novel Tetrahydroacridine Pyridine- Aldoxime and -amidoxime Hybrids As Efficient Uncharged Reactivators of Nerve Agent-inhibited Human Acetylcholinesterase

Overview
Journal Eur J Med Chem
Specialty Chemistry
Date 2014 Apr 8
PMID 24704618
Citations 20
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Abstract

A series of new uncharged functional acetylcholinesterase (AChE) reactivators including heterodimers of tetrahydroacridine with 3-hydroxy-2-pyridine aldoximes and amidoximes has been synthesized. These novel molecules display in vitro reactivation potencies towards VX-, tabun- and paraoxon-inhibited human AChE that are superior to those of the mono- and bis-pyridinium aldoximes currently used against nerve agent and pesticide poisoning. Furthermore, these uncharged compounds exhibit a broader reactivity spectrum compared to currently approved remediation drugs.

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