Cepharanthine Inhibited HIV-1 Cell-cell Transmission and Cell-free Infection Via Modification of Cell Membrane Fluidity

Overview

Journal Bioorg Med Chem Lett

Specialty Biochemistry

Date 2014 Apr 8

PMID 24704028

Citations 30

Authors

Kouki Matsuda

Shinichiro Hattori

Yuji Komizu

Ryusho Kariya

Ryuichi Ueoka

Seiji Okada

Affiliations

Soon will be listed here.

Abstract

The anti-HIV-1 activity of cepharanthine (CEP), a natural product derived from Stephania cepharantha Hayata, was evaluated. CEP stabilized plasma membrane fluidity and inhibited HIV-1 envelope-dependent cell-to-cell fusion of HIV-1-infected cells as well as cell-free infection. It is suggested that CEP inhibited the HIV-1 entry process by reducing plasma membrane fluidity, and the plasma membrane is therefore an identical target to prevent viral infection.

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