Impairment of the Ubiquitin-proteasome Pathway in RPE Alters the Expression of Inflammation Related Genes

Overview

Journal Adv Exp Med Biol

Specialties Biology
General Medicine

Date 2014 Mar 26

PMID 24664704

Citations 14

Authors

Zhenzhen Liu

Tingyu Qin

Jilin Zhou

Allen Taylor

Janet R Sparrow

Fu Shang

Affiliations

Soon will be listed here.

Abstract

The ubiquitin-proteasome pathway (UPP) plays an important role in regulating gene expression. Retinal pigment epithelial cells (RPE) are a major source of ocular inflammatory cytokines. In this work we determined the relationship between impairment of the UPP and expression of inflammation-related factors. The UPP could be impaired by oxidative stress or chemical inhibition. Impairment of the UPP in RPE increased the expression of several inflammatory cytokines, such as IL-6 and IL-8. However, the expression of monocyte chemoattractant protein-1 (MCP-1) and complement factor H (CFH) and was reduced upon impairment of the UPP. These data suggest that impairment of the UPP in RPE may be one of the causes of retinal inflammation and abnormal functions of monocyte and the complement system during the pathogenesis of age-related macular degeneration.

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