TNF and MAP Kinase Signalling Pathways

Overview

Journal Semin Immunol

Specialty Allergy & Immunology

Date 2014 Mar 21

PMID 24647229

Citations 324

Authors

Guadalupe Sabio

Roger J Davis

Affiliations

Soon will be listed here.

Abstract

The binding of tumour necrosis factor α (TNFα) to cell surface receptors engages multiple signal transduction pathways, including three groups of mitogen-activated protein (MAP) kinases: extracellular-signal-regulated kinases (ERKs); the cJun NH2-terminal kinases (JNKs); and the p38 MAP kinases. These MAP kinase signalling pathways induce a secondary response by increasing the expression of several inflammatory cytokines (including TNFα) that contribute to the biological activity of TNFα. MAP kinases therefore function both upstream and down-stream of signalling by TNFα receptors. Here we review mechanisms that mediate these actions of MAP kinases during the response to TNFα.

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