Targeting Innate Immunity Protein Kinase Signalling in Inflammation

Overview

Journal Nat Rev Drug Discov

Specialty Pharmacology

Date 2009 Jun 2

PMID 19483709

Citations 156

Authors

Matthias Gaestel

Alexey Kotlyarov

Michael Kracht

Affiliations

Soon will be listed here.

Abstract

Inflammation is an evolutionarily conserved host reaction that is initiated in response to trauma, tissue damage and infection. It leads to changes in tissue homeostasis and blood flow, immune-cell activation and migration, and secretion of cytokines and mediators in a spatio-temporally coordinated manner. Progress in understanding of the mechanisms of the inflammatory response has identified various protein kinases that act as essential signalling components and therefore represent potential therapeutic targets. This article summarizes advances in the identification and validation of such targets, and discusses key issues for the development of small-molecule kinase inhibitors as a new generation of oral anti-inflammatory drugs, including feedback loops, inhibitor specificity and combination therapy.

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