MicroRNA Gene Polymorphisms and Environmental Factors Increase Patient Susceptibility to Hepatocellular Carcinoma

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2014 Mar 4

PMID 24587132

Citations 30

Authors

Yin-Hung Chu

Ming-Ju Hsieh

Hui-Ling Chiou

Yi-Sheng Liou

Chen-Chieh Yang

Shun-Fa Yang

Wu-Hsien Kuo

Affiliations

Soon will be listed here.

Abstract

Background: Micro RNAs (miRNAs) are small RNA fragments that naturally exist in the human body. Through various physiological mechanisms, miRNAs can generate different functions for regulating RNA protein levels and balancing abnormalities. Abnormal miRNA expression has been reported to be highly related to several diseases and cancers. Single-nucleotide polymorphisms (SNPs) in miRNAs have been reported to increase patient susceptibility and affect patient prognosis and survival. We adopted a case-control research design to verify the relationship between miRNAs and hepatocellular carcinoma.

Methodology/principal Findings: A total of 525 subjects, including 377 controls and 188 hepatocellular carcinoma patients, were selected. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and real-time PCR were used to analyze miRNA146a (rs2910164), miRNA149 (rs2292832), miRNA196 (rs11614913), and miRNA499 (rs3746444) genetic polymorphisms between the control group and the case group. The results indicate that people who carry the rs3746444 CT or CC genotypes may have a significantly increased susceptibility to hepatocellular carcinoma (adjusted odds ratio [AOR] = 2.84, 95% confidence interval [CI] = 1.88-4.30). In addition, when combined with environmental risk factors, such as smoking and alcohol consumption, interaction effects were observed between gene polymorphisms and environmental factors (odds ratio [OR] = 4.69, 95% CI = 2.52-8.70; AOR = 3.38, 95% CI = 1.68-6.80).

Conclusions: These results suggest that a significant association exists between miRNA499 SNPs and hepatocellular carcinoma. Gene-environment interactions of miRNA499 polymorphisms, smoking, and alcohol consumption might alter hepatocellular carcinoma susceptibility.

Citing Articles

The Association between Four Common Polymorphisms in microRNA and Risk of Hepatocellular Carcinoma: An Updated Meta-Analysis.

Chen M, Lu Y, Wang X, Qin S, Chen H, Lu L Iran J Public Health. 2023; 52(11):2272-2285.

PMID: 38106842 PMC: 10719708. DOI: 10.18502/ijph.v52i11.14027.

Rs3746444 T>C locus in miR-499 increases the susceptibility to hepatocellular carcinoma: A meta-analysis 14812 subjects.

Jiang J, Chen H, Tang W, Chen Y, Lin J World J Gastrointest Oncol. 2023; 15(1):171-185.

PMID: 36684045 PMC: 9850759. DOI: 10.4251/wjgo.v15.i1.171.

Effect of rs11614913 Polymorphism on Cancer Susceptibility: Evidence From an Updated Meta-Analysis.

Aziz M, Akter T, Islam M Technol Cancer Res Treat. 2022; 21:15330338221109798.

PMID: 35770306 PMC: 9251994. DOI: 10.1177/15330338221109798.

The association between micro-RNA gene polymorphisms and the development of hepatocellular carcinoma in Egyptian patients.

Allam M, Diab K, Khalil F, Khalaf F, Abdel-Samiee M, Sheble N Arch Med Sci. 2022; 18(1):62-70.

PMID: 35154526 PMC: 8826692. DOI: 10.5114/aoms/100600.

Variants of MIRNA146A rs2910164 and MIRNA499 rs3746444 are associated with the development of cutaneous leishmaniasis caused by Leishmania guyanensis and with plasma chemokine IL-8.

de Mesquita T, Junior J, de Lacerda T, Queiroz K, Junior C, de Moura Neto J PLoS Negl Trop Dis. 2021; 15(9):e0009795.

PMID: 34543271 PMC: 8483412. DOI: 10.1371/journal.pntd.0009795.

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