Hsa-miR-499 Rs3746444 Polymorphism Contributes to Cancer Risk: a Meta-analysis of 12 Studies

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2012 Dec 14

PMID 23236400

Citations 24

Authors

Man-Tang Qiu

Jing-Wen Hu

Xiang-Xiang Ding

Xin Yang

Zhi Zhang

Rong Yin

Lin Xu

Affiliations

Soon will be listed here.

Abstract

Background: Single nucleotide polymorphisms (SNPs) occurred in pre-microRNAs or targets of microRNAs (miRs) may contribute to cancer risks. Since 2007, many studies have investigated the association between common SNPs located on hsa-miR-499 (rs3746444) and cancer risks; however, the results were inconclusive.

Methodology/principal Findings: We conducted a meta-analysis of 12 studies that included 5765 cases and 7076 controls to identify the strength of association. Odds ratio (OR) and 95% confidence intervals (95% CI) were used to assess the strength of association. Overall, individuals with the variant AG (OR = 1.215, 95% CI: 1.027, 1.437; P(heterogeneity)<0.01) and AG/GG (OR = 1.227, 95% CI: 1.046, 1.439; P(heterogeneity)<0.01) genotypes were associated with a significantly increased risk of cancer than those with wild AA genotype. Sub-group analysis revealed that the variant AG (OR = 1.411, 95% CI: 1.142, 1.745; P(heterogeneity) = 0.01) and AG/GG (OR = 1.413, 95% CI: 1.163, 1.717, P(heterogeneity) = 0.01) genotypes still showed an increased risk of cancer in Asians; however, a trend of reduced risk of cancer was observed in Caucasians (AG vs. AA: OR = 0.948, 955 CI: 0.851, 1.057, P(heterogeneity) = 0.12; AG/GG vs. AA: OR = 0.959, 95% CI: 0.865, 1.064; P(heterogeneity) = 0.19). Meta-regression showed that ethnicity (p = 0.048) and sample size (p = 0.02) but not cancer types (p = 0.89) or source of control (p = 0.97) were the sources of heterogeneity.

Conclusions: These meta-analysis results suggest that hsa-miR-499 polymorphism rs3746444 is associated with a significantly increased risk of cancer, especially in Asian populations.

Citing Articles

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Association of single nucleotide polymorphism in hsa-miR-499 and hsa-miR-196a2 with the risk of prostate cancer.

Nouri R, Ghorbian S Int Urol Nephrol. 2019; 51(5):811-816.

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