A MiR-182 Variant and Risk of Hepatocellular Carcinoma in a Southern Chinese Population

Overview

Journal Hum Genomics

Publisher Biomed Central

Specialty Genetics

Date 2020 Oct 16

PMID 33059751

Authors

Moqin Qiu

Yingchun Liu

Qiuling Lin

Zihan Zhou

Yanji Jiang

Rongrui Huo

Xiumei Liang

Xiangyuan Yu

Ji Cao

Xianguo Zhou

Hongping Yu

Affiliations

Soon will be listed here.

Abstract

MicroRNAs (miRNAs) play important roles in the regulation of gene expression at the posttranscriptional level and are involved in human carcinogenesis. The aim of the current study was to investigate the associations between miR-182 single nucleotide polymorphisms and HCC risk in a southern Chinese population. In this case-control study of 863 HCC patients and 908 cancer-free controls, we performed genotyping of miR-182 rs4541843 and assessed its association with HCC risk. We found that individuals carrying the AG/AA genotypes of miR-182 rs4541843 were significantly associated with an increased risk of HCC compared with those carrying the GG genotype (adjusted odds ratio (OR) = 1.71, 95% confidence interval (CI) = 1.07-2.76, P = 0.026). In the stratified analysis, this increased risk was more pronounced in the subgroups of older individuals (adjusted OR = 1.98, 95% CI = 1.04-3.76, P = 0.037), males (adjusted OR = 1.81, 95% CI = 1.09-2.99, P = 0.021), and never drinkers (adjusted OR = 1.84, 95% CI = 1.03-3.30, P = 0.041). Our results suggested that miR-182 polymorphism rs4541843 may contribute to the susceptibility to HCC. Our findings require validation in further studies with larger sample sizes.

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