MicroRNAs in Platelet Production and Activation

Overview

Journal Blood

Publisher Elsevier

Specialty Hematology

Date 2011 Mar 3

PMID 21364189

Citations 47

Authors

Leonard C Edelstein

Paul F Bray

Affiliations

Soon will be listed here.

Abstract

MicroRNAs are small RNA molecules that modulate protein expression by degrading mRNA or repressing translation. They have been shown to play important roles in hematopoiesis, including embryonic stem cell differentiation, erythropoiesis, granulocytopoiesis/monocytopoiesis, lymphopoiesis, and megakaryocytopoiesis. miR-150 and miR-155 play divergent roles in megakaryocytopoiesis, with the former promoting development of megakaryocytes at the expense of erythrocytes and the latter causing a reduction in megakaryocyte colony formation. Platelets also contain fully functional miRNA machinery, and certain miRNA levels in platelets have been found to coordinate with reactivity to specific agonists and to pathologic states. This review will cover the current state of knowledge of miRNAs in megakaryocytes and platelets and the exciting possibilities for future research.

Citing Articles

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Insights Into Platelet-Derived MicroRNAs in Cardiovascular and Oncologic Diseases: Potential Predictor and Therapeutic Target.

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References

Cheloufi S, Dos Santos C, Chong M, Hannon G . A dicer-independent miRNA biogenesis pathway that requires Ago catalysis. Nature. 2010; 465(7298):584-9. PMC: 2995450. DOI: 10.1038/nature09092. View

Bandiera S, Hatem E, Lyonnet S, Henrion-Caude A . microRNAs in diseases: from candidate to modifier genes. Clin Genet. 2010; 77(4):306-13. DOI: 10.1111/j.1399-0004.2010.01370.x. View

Lee Y, Kim M, Han J, Yeom K, Lee S, Baek S . MicroRNA genes are transcribed by RNA polymerase II. EMBO J. 2004; 23(20):4051-60. PMC: 524334. DOI: 10.1038/sj.emboj.7600385. View

Cai X, Hagedorn C, Cullen B . Human microRNAs are processed from capped, polyadenylated transcripts that can also function as mRNAs. RNA. 2004; 10(12):1957-66. PMC: 1370684. DOI: 10.1261/rna.7135204. View

Garzon R, Garofalo M, Martelli M, Briesewitz R, Wang L, Fernandez-Cymering C . Distinctive microRNA signature of acute myeloid leukemia bearing cytoplasmic mutated nucleophosmin. Proc Natl Acad Sci U S A. 2008; 105(10):3945-50. PMC: 2268779. DOI: 10.1073/pnas.0800135105. View

Borchert G, Lanier W, Davidson B . RNA polymerase III transcribes human microRNAs. Nat Struct Mol Biol. 2006; 13(12):1097-101. DOI: 10.1038/nsmb1167. View

Wienholds E, Kloosterman W, Miska E, Alvarez-Saavedra E, Berezikov E, de Bruijn E . MicroRNA expression in zebrafish embryonic development. Science. 2005; 309(5732):310-1. DOI: 10.1126/science.1114519. View

Fazi F, Rosa A, Fatica A, Gelmetti V, De Marchis M, Nervi C . A minicircuitry comprised of microRNA-223 and transcription factors NFI-A and C/EBPalpha regulates human granulopoiesis. Cell. 2005; 123(5):819-31. DOI: 10.1016/j.cell.2005.09.023. View

Xiao C, Calado D, Galler G, Thai T, Patterson H, Wang J . MiR-150 controls B cell differentiation by targeting the transcription factor c-Myb. Cell. 2007; 131(1):146-59. DOI: 10.1016/j.cell.2007.07.021. View

10.

Eis P, Tam W, Sun L, Chadburn A, Li Z, Gomez M . Accumulation of miR-155 and BIC RNA in human B cell lymphomas. Proc Natl Acad Sci U S A. 2005; 102(10):3627-32. PMC: 552785. DOI: 10.1073/pnas.0500613102. View

11.

Lu J, Guo S, Ebert B, Zhang H, Peng X, Bosco J . MicroRNA-mediated control of cell fate in megakaryocyte-erythrocyte progenitors. Dev Cell. 2008; 14(6):843-53. PMC: 2688789. DOI: 10.1016/j.devcel.2008.03.012. View

12.

Zhou B, Wang S, Mayr C, Bartel D, Lodish H . miR-150, a microRNA expressed in mature B and T cells, blocks early B cell development when expressed prematurely. Proc Natl Acad Sci U S A. 2007; 104(17):7080-5. PMC: 1855395. DOI: 10.1073/pnas.0702409104. View

13.

Dore L, Amigo J, Dos Santos C, Zhang Z, Gai X, Tobias J . A GATA-1-regulated microRNA locus essential for erythropoiesis. Proc Natl Acad Sci U S A. 2008; 105(9):3333-8. PMC: 2265118. DOI: 10.1073/pnas.0712312105. View

14.

Ramkissoon S, Mainwaring L, Ogasawara Y, Keyvanfar K, McCoy Jr J, Sloand E . Hematopoietic-specific microRNA expression in human cells. Leuk Res. 2005; 30(5):643-7. DOI: 10.1016/j.leukres.2005.09.001. View

15.

Xu W, Li J . MicroRNA gene expression in malignant lymphoproliferative disorders. Chin Med J (Engl). 2007; 120(11):996-9. View

16.

Friedman R, Farh K, Burge C, Bartel D . Most mammalian mRNAs are conserved targets of microRNAs. Genome Res. 2008; 19(1):92-105. PMC: 2612969. DOI: 10.1101/gr.082701.108. View

17.

Sethupathy P, Collins F . MicroRNA target site polymorphisms and human disease. Trends Genet. 2008; 24(10):489-97. DOI: 10.1016/j.tig.2008.07.004. View

18.

Klusmann J, Li Z, Bohmer K, Maroz A, Koch M, Emmrich S . miR-125b-2 is a potential oncomiR on human chromosome 21 in megakaryoblastic leukemia. Genes Dev. 2010; 24(5):478-90. PMC: 2827843. DOI: 10.1101/gad.1856210. View

19.

Warshaw A, LASTER L, Shulman N . The stimulation by thrombin of glucose oxidation in human platelets. J Clin Invest. 1966; 45(12):1923-34. PMC: 292878. DOI: 10.1172/JCI105497. View

20.

Yuan A, Farber E, Rapoport A, Tejada D, Deniskin R, Akhmedov N . Transfer of microRNAs by embryonic stem cell microvesicles. PLoS One. 2009; 4(3):e4722. PMC: 2648987. DOI: 10.1371/journal.pone.0004722. View