Theories and Quantification of Thymic Selection

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2014 Feb 20

PMID 24550908

Citations 46

Authors

Andrew J Yates

Affiliations

Soon will be listed here.

Abstract

The peripheral T cell repertoire is sculpted from prototypic T cells in the thymus bearing randomly generated T cell receptors (TCR) and by a series of developmental and selection steps that remove cells that are unresponsive or overly reactive to self-peptide-MHC complexes. The challenge of understanding how the kinetics of T cell development and the statistics of the selection processes combine to provide a diverse but self-tolerant T cell repertoire has invited quantitative modeling approaches, which are reviewed here.

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