Stochastic Component to Development of Class I Major Histocompatibility Complex-specific T Cells

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1994 Jan 4

PMID 7904067

Citations 11

Authors

A Itano

D Kioussis

E Robey

Affiliations

Soon will be listed here.

Abstract

The mechanism by which an initially uncommitted cell chooses between alternative fates is a central issue in developmental biology. In the mammalian thymus, CD4 helper T cells and CD8 cytotoxic T cells arise from a common precursor that expresses both CD4 and CD8. The choice between the CD4 and CD8 lineage is linked to the specificity of the T-cell antigen receptor expressed by a thymocyte, but whether lineage commitment is stochastic or instructed has not been definitively resolved. We present evidence that expression of a constitutive CD8 transgene during thymic selection permits development of mature CD4 cells bearing the class I-restricted F5 T-cell antigen receptor. These results suggest that there is a stochastic component to the development of class I major histocompatibility complex-restricted T cells.

Citing Articles

Adjusting to self in the thymus: CD4 versus CD8 lineage commitment and regulatory T cell development.

Baldwin I, Robey E J Exp Med. 2024; 221(10).

PMID: 38980291 PMC: 11232887. DOI: 10.1084/jem.20230896.

Theories and quantification of thymic selection.

Yates A Front Immunol. 2014; 5:13.

PMID: 24550908 PMC: 3912788. DOI: 10.3389/fimmu.2014.00013.

Targeting CD4 coreceptor expression to postselection thymocytes reveals that CD4/CD8 lineage choice is neither error-prone nor stochastic.

Adoro S, Erman B, Sarafova S, Van Laethem F, Park J, Feigenbaum L J Immunol. 2008; 181(10):6975-83.

PMID: 18981117 PMC: 7217309. DOI: 10.4049/jimmunol.181.10.6975.

Lineage fate and intense debate: myths, models and mechanisms of CD4- versus CD8-lineage choice.

Singer A, Adoro S, Park J Nat Rev Immunol. 2008; 8(10):788-801.

PMID: 18802443 PMC: 2760737. DOI: 10.1038/nri2416.

Visualization of CD4/CD8 T cell commitment.

Chan S, Correia-Neves M, Dierich A, Benoist C, Mathis D J Exp Med. 1998; 188(12):2321-33.

PMID: 9858518 PMC: 2212422. DOI: 10.1084/jem.188.12.2321.

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