Affinity Threshold for Thymic Selection Through a T-cell Receptor-co-receptor Zipper

Overview

Journal Nat Rev Immunol

Specialty Allergy & Immunology

Date 2009 Jan 20

PMID 19151748

Citations 72

Authors

Ed Palmer

Dieter Naeher

Affiliations

Soon will be listed here.

Abstract

The affinity of the T-cell receptor (TCR) for self antigen is the basis for the selection of a useful (MHC-restricted) and safe (self-tolerant) T-cell repertoire. However, it has been difficult to understand how thymocytes measure ligand affinity and translate this signal into a cellular response. In this Opinion article, we propose a new model that describes how the TCR discriminates between low- and high-affinity ligands, which is based on the duration of TCR-ligand interactions and a 'zipper' mechanism that mediates the interaction of the TCR and co-receptor molecules to initiate negative-selection signalling.

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