Effects of Rutin on Acrylamide-induced Neurotoxicity

Overview

Journal Daru

Specialty Pharmacology

Date 2014 Feb 15

PMID 24524427

Citations 12

Authors

Vahideh Sadat Motamedshariaty

Sara Amel Farzad

Marjan Nassiri-Asl

Hossein Hosseinzadeh

Affiliations

Soon will be listed here.

Abstract

Background: Rutin is an important flavonoid that is consumed in the daily diet. The cytoprotective effects of rutin, including antioxidative, and neuroprotective have been shown in several studies. Neurotoxic effects of acrylamide (ACR) have been established in humans and animals. In this study, the protective effects of rutin in prevention and treatment of neural toxicity of ACR were studied.

Results: Rutin significantly reduced cell death induced by ACR (5.46 mM) in time- and dose-dependent manners. Rutin treatment decreased the ACR-induced cytotoxicity significantly in comparison to control (P <0.01, P < 0.001). Rutin (100 and 200 mg/kg) could prevent decrease of body weight in rats. In combination treatments with rutin (50, 100 and 200 mg/kg), vitamin E (200 mg/kg) and ACR, gait abnormalities significantly decreased in a dose-dependent manner (P < 0.01 and P < 0.001). The level of malondialdehyde significantly decreased in the brain tissue of rats in both preventive and therapeutic groups that received rutin (100 and 200 mg/kg).

Conclusion: It seems that rutin could be effective in reducing neurotoxicity and the neuroprotective effect of it might be mediated via antioxidant activity.

Citing Articles

Concomitant administration of resveratrol and resistance training ameliorates acrylamide-induced spatial learning impairment in rats.

Hemat Jouy S, Shahraki J, Rezaee R, Ghorani V, Gholami M Avicenna J Phytomed. 2024; 14(2):177-188.

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and effects of crocetin and its amide derivative on acrylamide-induced neurotoxicity.

Ajzashokouhi A, Razavi B, Sadeghian H, Hosseinzadeh H Avicenna J Phytomed. 2024; 14(1):78-89.

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Bisphosphonate's effect on the tongue in adult male albino rats and the possible protective role of rutin: light and scanning electron microscopic study.

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Blueberry Anthocyanins Extract Attenuates Acrylamide-Induced Oxidative Stress and Neuroinflammation in Rats.

Fang Z, Luo Y, Ma C, Dong L, Chen F Oxid Med Cell Longev. 2022; 2022:7340881.

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A Novel Approach to Unraveling the Apoptotic Potential of Rutin (Bioflavonoid) via Targeting in Cervical Cancer Cells.

Pandey P, Khan F, Alzahrani F, Qari H, Oves M Molecules. 2021; 26(18).

PMID: 34577000 PMC: 8472561. DOI: 10.3390/molecules26185529.

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