Protective Effect of Rosemary on Acrylamide Motor Neurotoxicity in Spinal Cord of Rat Offspring: Postnatal Follow-up Study

Overview

Journal Anat Cell Biol

Specialty Anatomy & Histology

Date 2016 Apr 7

PMID 27051566

Citations 5

Authors

Marwa A Al-Gholam

Hanaa Zakaria Nooh

Abeer E El-Mehi

Abd El-Moneum El-Barbary

Ahmed Zo El Fokar

Affiliations

Soon will be listed here.

Abstract

The direct interactive effects of rosemary and acrylamide on the development of motor neurons in the spinal cord remains unknown. Our goal is to confirm the protective effects of rosemary against motor neuronal degeneration induced by acrylamide in the developing postnatal rat spinal cord using a postnatal rat model. We assigned the offspring of treated female rats into control, rosemary; acrylamide group; and recovery groups. This work depended on clinical, histopathological, morphometrically, immunohistochemical and genetic methods. In the acrylamide group, we observed oxidation, motor neuron degeneration, apoptosis, myelin degeneration, neurofilament reduction, reactive gliosis. Whoever, concomitant rosemary intake and withdrawal of acrylamide modulate these effects. These findings proof that dietary rosemary can directly protect motor neuron against acrylamide toxicity in the mammalian developing spinal cord.

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References

Yao X, Yan L, Yao L, Guan W, Zeng F, Cao F . Acrylamide exposure impairs blood-cerebrospinal fluid barrier function. Neural Regen Res. 2014; 9(5):555-60. PMC: 4153501. DOI: 10.4103/1673-5374.130080. View

Allam A, El-Ghareeb A, Abdul-Hamid M, Baikry A, Sabri M . Prenatal and perinatal acrylamide disrupts the development of cerebellum in rat: Biochemical and morphological studies. Toxicol Ind Health. 2011; 27(4):291-306. DOI: 10.1177/0748233710386412. View

Erkan N, Ayranci G, Ayranci E . Antioxidant activities of rosemary (Rosmarinus Officinalis L.) extract, blackseed (Nigella sativa L.) essential oil, carnosic acid, rosmarinic acid and sesamol. Food Chem. 2015; 110(1):76-82. DOI: 10.1016/j.foodchem.2008.01.058. View

Inoue K, Takano H, Shiga A, Fujita Y, Makino H, Yanagisawa R . Effects of volatile constituents of rosemary extract on lung inflammation induced by diesel exhaust particles. Basic Clin Pharmacol Toxicol. 2006; 99(1):52-7. DOI: 10.1111/j.1742-7843.2006.pto_401.x. View

Yu S, Zhao X, Zhang T, Yu L, Li S, Cui N . Acrylamide-induced changes in the neurofilament protein of rat cerebrum fractions. Neurochem Res. 2005; 30(9):1079-85. DOI: 10.1007/s11064-005-7413-3. View

Ito N, Yabe T, Gamo Y, Nagai T, Oikawa T, Yamada H . Rosmarinic acid from Perillae Herba produces an antidepressant-like effect in mice through cell proliferation in the hippocampus. Biol Pharm Bull. 2008; 31(7):1376-80. DOI: 10.1248/bpb.31.1376. View

Fuhr U, Boettcher M, Kinzig-Schippers M, Weyer A, Jetter A, Lazar A . Toxicokinetics of acrylamide in humans after ingestion of a defined dose in a test meal to improve risk assessment for acrylamide carcinogenicity. Cancer Epidemiol Biomarkers Prev. 2006; 15(2):266-71. DOI: 10.1158/1055-9965.EPI-05-0647. View

Guo C, Li B, Xiao J . [General survey of mechanisms of acrylamide neurotoxicity]. Wei Sheng Yan Jiu. 2010; 39(3):282-5. View

Hogervorst J, Baars B, Schouten L, Konings E, Goldbohm R, van den Brandt P . The carcinogenicity of dietary acrylamide intake: a comparative discussion of epidemiological and experimental animal research. Crit Rev Toxicol. 2010; 40(6):485-512. DOI: 10.3109/10408440903524254. View

10.

Klaunig J, Kamendulis L . Mechanisms of acrylamide induced rodent carcinogenesis. Adv Exp Med Biol. 2006; 561:49-62. DOI: 10.1007/0-387-24980-X_4. View

11.

Satoh T, Kosaka K, Itoh K, Kobayashi A, Yamamoto M, Shimojo Y . Carnosic acid, a catechol-type electrophilic compound, protects neurons both in vitro and in vivo through activation of the Keap1/Nrf2 pathway via S-alkylation of targeted cysteines on Keap1. J Neurochem. 2007; 104(4):1116-31. PMC: 4566957. DOI: 10.1111/j.1471-4159.2007.05039.x. View

12.

Chen W, Feng L, Shen Y, Su H, Li Y, Zhuang J . Myricitrin inhibits acrylamide-mediated cytotoxicity in human Caco-2 cells by preventing oxidative stress. Biomed Res Int. 2013; 2013:724183. PMC: 3809942. DOI: 10.1155/2013/724183. View

13.

Moss M, Cook J, Wesnes K, Duckett P . Aromas of rosemary and lavender essential oils differentially affect cognition and mood in healthy adults. Int J Neurosci. 2003; 113(1):15-38. DOI: 10.1080/00207450390161903. View

14.

Ozarowski M, Mikolajczak P, Bogacz A, Gryszczynska A, Kujawska M, Jodynis-Liebert J . Rosmarinus officinalis L. leaf extract improves memory impairment and affects acetylcholinesterase and butyrylcholinesterase activities in rat brain. Fitoterapia. 2013; 91:261-271. DOI: 10.1016/j.fitote.2013.09.012. View

15.

Motamedshariaty V, Farzad S, Nassiri-Asl M, Hosseinzadeh H . Effects of rutin on acrylamide-induced neurotoxicity. Daru. 2014; 22(1):27. PMC: 3927829. DOI: 10.1186/2008-2231-22-27. View

16.

Martyniuk C, Feswick A, Fang B, Koomen J, Barber D, Gavin T . Protein targets of acrylamide adduct formation in cultured rat dopaminergic cells. Toxicol Lett. 2013; 219(3):279-87. PMC: 3707521. DOI: 10.1016/j.toxlet.2013.03.031. View

17.

Singh N, McCoy M, Tice R, Schneider E . A simple technique for quantitation of low levels of DNA damage in individual cells. Exp Cell Res. 1988; 175(1):184-91. DOI: 10.1016/0014-4827(88)90265-0. View

18.

Tyl R, Marr M, Myers C, ROSS W, Friedman M . Relationship between acrylamide reproductive and neurotoxicity in male rats. Reprod Toxicol. 2000; 14(2):147-57. DOI: 10.1016/s0890-6238(00)00066-6. View

19.

Wang H, Ge J, Zhou Z, Wang Z, Shi F . [Oral acrylamide affects the development and reproductive performance of male rats]. Zhonghua Nan Ke Xue. 2007; 13(6):492-7. View

20.

Lopachin R, Ross J, Reid M, Das S, Mansukhani S, Lehning E . Neurological evaluation of toxic axonopathies in rats: acrylamide and 2,5-hexanedione. Neurotoxicology. 2002; 23(1):95-110. DOI: 10.1016/s0161-813x(02)00003-7. View