Blueberry Anthocyanins Extract Attenuates Acrylamide-Induced Oxidative Stress and Neuroinflammation in Rats

Overview

Journal Oxid Med Cell Longev

Publisher Wiley

Specialties Cell Biology
Endocrinology

Date 2022 Jun 2

PMID 35651724

Authors

Zizhuang Fang

Yinghua Luo

Chen Ma

Li Dong

Fang Chen

Affiliations

Soon will be listed here.

Abstract

Acrylamide (AA) is a widespread environmental and dietary-derived neurotoxin, which can induce oxidative stress and associated inflammation in the brain. Anthocyanins widely occur as natural antioxidant and anti-inflammatory phytochemicals. Herein, the protective effects of blueberry anthocyanins extract (BAE) against AA-induced neurotoxicity were investigated in rats. The rats were pretreated with BAE (175 mg/kg body weight/day) by oral gavage for the first 7 days, followed by the co-administration of BAE and AA (35 mg/kg body weight/day) by oral gavage for the next 12 days. Results showed that BAE significantly decreased the malondialdehyde (MDA) production, and increased glutathione (GSH) and antioxidant enzyme levels; and it also suppressed microglial activation, astrocytic reaction, and pro-inflammatory cytokine expressions. Furthermore, BAE elevated the extracellular signal-related kinase (ERK)/cAMP response elements binding protein (CREB)/brain-derived neurotrophic factor (BDNF) pathway, and relieved the accumulation of amyloid beta (A) 1-42 and 1-40 after AA exposure. Consequently, AA-induced neuronal necrosis and downregulation of synaptosomal-associated protein 25 (SNAP-25) were attenuated by BAE in the hippocampus and cerebral cortex. In conclusion, BAE can exert a protective function on neurons and synapses against AA-induced oxidative stress and neuroinflammation.

Citing Articles

Antioxidant Activity of Anthocyanins and Anthocyanidins: A Critical Review.

Sadowska-Bartosz I, Bartosz G Int J Mol Sci. 2024; 25(22).

PMID: 39596068 PMC: 11593439. DOI: 10.3390/ijms252212001.

Strategies to reduce neurotoxic acrylamide in biscuits, a systematic review.

Ghanati K, Shafaroodi H, Basaran B, Moslemizadeh A, Mahdavi V, Sadighara M Toxicol Rep. 2024; 13:101751.

PMID: 39399097 PMC: 11470260. DOI: 10.1016/j.toxrep.2024.101751.

The antioxidant protective effect of resveratrol on long-term exposure to acrylamide-induced skeletal toxicity in female mice.

Zhang H, Liu Y, Wen Y, Wang H, Chen L Toxicol Res (Camb). 2024; 13(4):tfae109.

PMID: 39036523 PMC: 11256996. DOI: 10.1093/toxres/tfae109.

Chronic and postprandial effect of blueberries on cognitive function, alertness, and mood in participants with metabolic syndrome - results from a six-month, double-blind, randomized controlled trial.

Curtis P, van der Velpen V, Berends L, Jennings A, Haag L, Minihane A Am J Clin Nutr. 2024; 119(3):658-668.

PMID: 38432713 PMC: 10972710. DOI: 10.1016/j.ajcnut.2023.12.006.

Exploring the Impact of Cyanidin-3-Glucoside on Inflammatory Bowel Diseases: Investigating New Mechanisms for Emerging Interventions.

Frountzas M, Karanikki E, Toutouza O, Sotirakis D, Schizas D, Theofilis P Int J Mol Sci. 2023; 24(11).

PMID: 37298350 PMC: 10254033. DOI: 10.3390/ijms24119399.

References

Chen X, Xiao J, Cao P, Zhang Y, Cai W, Song J . Brain-derived neurotrophic factor protects against acrylamide-induced neuronal and synaptic injury via the TrkB-MAPK-Erk1/2 pathway. Neural Regen Res. 2020; 16(1):150-157. PMC: 7818888. DOI: 10.4103/1673-5374.286976. View

Wu H, Yu Y, Li X, Lang X, Gu R, Fan S . Edaravone attenuates HO or glutamate-induced toxicity in hippocampal neurons and improves AlCl/D-galactose induced cognitive impairment in mice. Neurotoxicology. 2021; 85:68-78. DOI: 10.1016/j.neuro.2021.05.005. View

Ali T, Kim T, Rehman S, Khan M, Ul Amin F, Khan M . Natural Dietary Supplementation of Anthocyanins via PI3K/Akt/Nrf2/HO-1 Pathways Mitigate Oxidative Stress, Neurodegeneration, and Memory Impairment in a Mouse Model of Alzheimer's Disease. Mol Neurobiol. 2017; 55(7):6076-6093. DOI: 10.1007/s12035-017-0798-6. View

Khan M, Ali T, Kim M, Jo M, Chung J, Kim M . Anthocyanins Improve Hippocampus-Dependent Memory Function and Prevent Neurodegeneration via JNK/Akt/GSK3β Signaling in LPS-Treated Adult Mice. Mol Neurobiol. 2018; 56(1):671-687. DOI: 10.1007/s12035-018-1101-1. View

Ge L, Liu L, Liu H, Liu S, Xue H, Wang X . Resveratrol abrogates lipopolysaccharide-induced depressive-like behavior, neuroinflammatory response, and CREB/BDNF signaling in mice. Eur J Pharmacol. 2015; 768:49-57. DOI: 10.1016/j.ejphar.2015.10.026. View

Yoshida Yamakawa M, Uchino K, Watanabe Y, Adachi T, Nakanishi M, Ichino H . Anthocyanin suppresses the toxicity of Aβ deposits through diversion of molecular forms in in vitro and in vivo models of Alzheimer's disease. Nutr Neurosci. 2015; 19(1):32-42. DOI: 10.1179/1476830515Y.0000000042. View

Antonucci F, Corradini I, Fossati G, Tomasoni R, Menna E, Matteoli M . SNAP-25, a Known Presynaptic Protein with Emerging Postsynaptic Functions. Front Synaptic Neurosci. 2016; 8:7. PMC: 4805587. DOI: 10.3389/fnsyn.2016.00007. View

Li Y, Ma R, Xu Z, Wang J, Chen T, Chen F . Identification and quantification of anthocyanins in Kyoho grape juice-making pomace, Cabernet Sauvignon grape winemaking pomace and their fresh skin. J Sci Food Agric. 2013; 93(6):1404-11. DOI: 10.1002/jsfa.5907. View

Erkekoglu P, Baydar T . Acrylamide neurotoxicity. Nutr Neurosci. 2013; 17(2):49-57. DOI: 10.1179/1476830513Y.0000000065. View

10.

Hussain T, Tan B, Yin Y, Blachier F, Tossou M, Rahu N . Oxidative Stress and Inflammation: What Polyphenols Can Do for Us?. Oxid Med Cell Longev. 2016; 2016:7432797. PMC: 5055983. DOI: 10.1155/2016/7432797. View

11.

Amidfar M, de Oliveira J, Kucharska E, Budni J, Kim Y . The role of CREB and BDNF in neurobiology and treatment of Alzheimer's disease. Life Sci. 2020; 257:118020. DOI: 10.1016/j.lfs.2020.118020. View

12.

Bjorklund G, Peana M, Maes M, Dadar M, Severin B . The glutathione system in Parkinson's disease and its progression. Neurosci Biobehav Rev. 2020; 120:470-478. DOI: 10.1016/j.neubiorev.2020.10.004. View

13.

Kim M, Rehman S, Ul Amin F, Kim M . Enhanced neuroprotection of anthocyanin-loaded PEG-gold nanoparticles against Aβ-induced neuroinflammation and neurodegeneration via the NF-B /JNK/GSK3β signaling pathway. Nanomedicine. 2017; 13(8):2533-2544. DOI: 10.1016/j.nano.2017.06.022. View

14.

Motamedshariaty V, Farzad S, Nassiri-Asl M, Hosseinzadeh H . Effects of rutin on acrylamide-induced neurotoxicity. Daru. 2014; 22(1):27. PMC: 3927829. DOI: 10.1186/2008-2231-22-27. View

15.

Chen S, Zhou H, Zhang G, Meng J, Deng K, Zhou W . Anthocyanins from Lycium ruthenicum Murr. Ameliorated d-Galactose-Induced Memory Impairment, Oxidative Stress, and Neuroinflammation in Adult Rats. J Agric Food Chem. 2019; 67(11):3140-3149. DOI: 10.1021/acs.jafc.8b06402. View

16.

Yan D, Yao J, Liu Y, Zhang X, Wang Y, Chen X . Tau hyperphosphorylation and P-CREB reduction are involved in acrylamide-induced spatial memory impairment: Suppression by curcumin. Brain Behav Immun. 2018; 71:66-80. DOI: 10.1016/j.bbi.2018.04.014. View

17.

Rehman S, Shah S, Ali T, Chung J, Kim M . Anthocyanins Reversed D-Galactose-Induced Oxidative Stress and Neuroinflammation Mediated Cognitive Impairment in Adult Rats. Mol Neurobiol. 2016; 54(1):255-271. DOI: 10.1007/s12035-015-9604-5. View

18.

Sharma P, Sharma S, Singh D . Apigenin reverses behavioural impairments and cognitive decline in kindled mice via CREB-BDNF upregulation in the hippocampus. Nutr Neurosci. 2018; 23(2):118-127. DOI: 10.1080/1028415X.2018.1478653. View

19.

Ma H, Johnson S, Liu W, DaSilva N, Meschwitz S, Dain J . Evaluation of Polyphenol Anthocyanin-Enriched Extracts of Blackberry, Black Raspberry, Blueberry, Cranberry, Red Raspberry, and Strawberry for Free Radical Scavenging, Reactive Carbonyl Species Trapping, Anti-Glycation, Anti-β-Amyloid Aggregation,.... Int J Mol Sci. 2018; 19(2). PMC: 5855683. DOI: 10.3390/ijms19020461. View

20.

Santana-Martinez R, Silva-Islas C, Fernandez-Orihuela Y, Barrera-Oviedo D, Pedraza-Chaverri J, Hernandez-Pando R . The Therapeutic Effect of Curcumin in Quinolinic Acid-Induced Neurotoxicity in Rats is Associated with BDNF, ERK1/2, Nrf2, and Antioxidant Enzymes. Antioxidants (Basel). 2019; 8(9). PMC: 6769626. DOI: 10.3390/antiox8090388. View