Bone Marrow Mesenchymal Stem Cells and TGF-β Signaling in Bone Remodeling

Overview

Journal J Clin Invest

Specialty General Medicine

Date 2014 Feb 4

PMID 24487640

Citations 212

Authors

Janet L Crane

Xu Cao

Affiliations

Soon will be listed here.

Abstract

During bone resorption, abundant factors previously buried in the bone matrix are released into the bone marrow microenvironment, which results in recruitment and differentiation of bone marrow mesenchymal stem cells (MSCs) for subsequent bone formation, temporally and spatially coupling bone remodeling. Parathyroid hormone (PTH) orchestrates the signaling of many pathways that direct MSC fate. The spatiotemporal release and activation of matrix TGF-β during osteoclast bone resorption recruits MSCs to bone-resorptive sites. Dysregulation of TGF-β alters MSC fate, uncoupling bone remodeling and causing skeletal disorders. Modulation of TGF-β or PTH signaling may reestablish coupled bone remodeling and be a potential therapy.

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