In Vivo Optical Spectroscopy for Improved Detection of Pancreatic Adenocarcinoma: a Feasibility Study

Overview

Journal Biomed Opt Express

Specialty Radiology

Date 2014 Jan 28

PMID 24466472

Citations 9

Authors

William R Lloyd

Robert H Wilson

Seung Yup Lee

Malavika Chandra

Barbara McKenna

Diane Simeone

James Scheiman

Mary-Ann Mycek

Affiliations

Soon will be listed here.

Abstract

Pancreatic adenocarcinoma has a five-year survival rate of less than 6%. This low survival rate is attributed to the lack of accurate detection methods, which limits diagnosis to late-stage disease. Here, an in vivo pilot study assesses the feasibility of optical spectroscopy to improve clinical detection of pancreatic adenocarcinoma. During surgery on 6 patients, we collected spectrally-resolved reflectance and fluorescence in vivo. Site-matched in vivo and ex vivo data agreed qualitatively and quantitatively. Quantified differences between adenocarcinoma and normal tissues in vivo were consistent with previous results from a large ex vivo data set. Thus, optical spectroscopy is a promising method for the improved diagnosis of pancreatic cancer in vivo.

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