Characterizing Human Pancreatic Cancer Precursor Using Quantitative Tissue Optical Spectroscopy

Overview

Journal Biomed Opt Express

Specialty Radiology

Date 2014 Jan 11

PMID 24409383

Citations 13

Authors

Seung Yup Lee

William R Lloyd

Malavika Chandra

Robert H Wilson

Barbara McKenna

Diane Simeone

James Scheiman

Mary-Ann Mycek

Affiliations

Soon will be listed here.

Abstract

In a pilot study, multimodal optical spectroscopy coupled with quantitative tissue-optics models distinguished intraductal papillary mucinous neoplasm (IPMN), a common precursor to pancreatic cancer, from normal tissues in freshly excised human pancreas. A photon-tissue interaction (PTI) model extracted parameters associated with cellular nuclear size and refractive index (from reflectance spectra) and extracellular collagen content (from fluorescence spectra). The results suggest that tissue optical spectroscopy has the potential to characterize pre-cancerous neoplasms in human pancreatic tissues.

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