Antioxidant Activity and Free Radical Scavenging Capacity of Phenolic Extracts from Helicteres Isora L. and Ceiba Pentandra L

Overview

Journal J Food Sci Technol

Specialty Nutritional Sciences

Date 2014 Jan 16

PMID 24425970

Citations 56

Authors

Nataraj Loganayaki

Perumal Siddhuraju

Sellamuthu Manian

Affiliations

Soon will be listed here.

Abstract

In the present study, antioxidant activities of the phenolic extracts from H. isora fruits and C. pentandra seeds were investigated by employing established in vitro systems, which included reducing power, OH(●), DPPH(●), ABTS(●+), linoleic acid emulsion, metal chelation and antihemolytic activity. The extracts of C. pentandra contained relatively higher levels of total phenolics and flavonoids than those of H. isora. All the extracts showed dose dependent reducing power activity and moreover, they were well correlated with the total phenolic substances. A similar dose dependant trend has also been observed for hydroxyl radical scavenging activity and DPPH(●) radical scavenging activity. Further, addition of 250 μg of extracts to the reaction mixture produced 41.3-54.6% peroxidation inhibiting activity during 60 h of incubation. The potential of multiple antioxidant activity of samples can be further evidenced by inhibition of reactive oxygen mediated erythrocyte cell lysis and metal ion chelating activity.

Citing Articles

Sea urchin waste as valuable alternative source of calcium in laying hens' diet.

Leone F, Sugni M, Marzorati S, Rizzato S, Ferrari L, Tremolada P PLoS One. 2025; 20(3):e0314981.

PMID: 40036236 PMC: 11878918. DOI: 10.1371/journal.pone.0314981.

Revealing the antioxidant properties of alkyl gallates: a novel approach through quantum chemical calculations and molecular docking.

Karakus N J Mol Model. 2024; 30(12):401.

PMID: 39542935 DOI: 10.1007/s00894-024-06196-5.

Unveiling the influences of P fertilization on bioactive compounds and antioxidant activity in grains of four sorghum cultivars.

Elsafy M, Tia N, Sir Elkhatim K, Othman M, Hassan A, Rahmatov M PLoS One. 2024; 19(10):e0311756.

PMID: 39480873 PMC: 11527271. DOI: 10.1371/journal.pone.0311756.

Assessment of the in vitro anti-diabetic activity with molecular dynamic simulations of limonoids isolated from Adalia lemon peels.

El-Feky A, Aboulthana W, El-Rashedy A Sci Rep. 2024; 14(1):21478.

PMID: 39277638 PMC: 11401861. DOI: 10.1038/s41598-024-71198-5.

Assessment of Multifunctional Activity of a Postbiotic Preparation Derived from Postbiotic-P6.

Dong H, Ren X, Song Y, Zhang J, Zhuang H, Peng C Foods. 2024; 13(15).

PMID: 39123515 PMC: 11312004. DOI: 10.3390/foods13152326.

References

Rice-Evans C, Miller N, Paganga G . Structure-antioxidant activity relationships of flavonoids and phenolic acids. Free Radic Biol Med. 1996; 20(7):933-56. DOI: 10.1016/0891-5849(95)02227-9. View

Chaudhuri S, Banerjee A, Basu K, Sengupta B, Sengupta P . Interaction of flavonoids with red blood cell membrane lipids and proteins: antioxidant and antihemolytic effects. Int J Biol Macromol. 2007; 41(1):42-8. DOI: 10.1016/j.ijbiomac.2006.12.003. View

Kumar G, Murugesan A . Hypolipidaemic activity of Helicteres isora L. bark extracts in streptozotocin induced diabetic rats. J Ethnopharmacol. 2008; 116(1):161-6. DOI: 10.1016/j.jep.2007.11.020. View

Heim K, Tagliaferro A, Bobilya D . Flavonoid antioxidants: chemistry, metabolism and structure-activity relationships. J Nutr Biochem. 2003; 13(10):572-584. DOI: 10.1016/s0955-2863(02)00208-5. View

Kumar G, Murugesan A, Pandian M . Effect of Helicteres isora bark extract on blood glucose and hepatic enzymes in experimental diabetes. Pharmazie. 2006; 61(4):353-5. View

Re R, Pellegrini N, Proteggente A, Pannala A, Yang M . Antioxidant activity applying an improved ABTS radical cation decolorization assay. Free Radic Biol Med. 1999; 26(9-10):1231-7. DOI: 10.1016/s0891-5849(98)00315-3. View

Lee J, Koo N, Min D . Reactive Oxygen Species, Aging, and Antioxidative Nutraceuticals. Compr Rev Food Sci Food Saf. 2021; 3(1):21-33. DOI: 10.1111/j.1541-4337.2004.tb00058.x. View

Hagerman A, Riedl K, Jones G, Sovik K, Ritchard N, Hartzfeld P . High Molecular Weight Plant Polyphenolics (Tannins) as Biological Antioxidants. J Agric Food Chem. 2017; 46(5):1887-1892. DOI: 10.1021/jf970975b. View

Ngounou F, Meli A, Lontsi D, Sondengam B, Atta-Ur-Rahman , Choudhary M . New isoflavones from Ceiba pentandra. Phytochemistry. 2000; 54(1):107-10. DOI: 10.1016/s0031-9422(00)00035-2. View

10.

Yamaguchi F, Yoshimura Y, Nakazawa H, Ariga T . Free radical scavenging activity of grape seed extract and antioxidants by electron spin resonance spectrometry in an H(2)O(2)/NaOH/DMSO system. J Agric Food Chem. 1999; 47(7):2544-8. DOI: 10.1021/jf9806762. View

11.

Yamaguchi F, Ariga T, Yoshimura Y, Nakazawa H . Antioxidative and anti-glycation activity of garcinol from Garcinia indica fruit rind. J Agric Food Chem. 2000; 48(2):180-5. DOI: 10.1021/jf990845y. View

12.

Naim M, GESTETNER B, Bondi A, Birk Y . Antioxidative and antihemolytic activities of soybean isoflavones. J Agric Food Chem. 1976; 24(6):1174-7. DOI: 10.1021/jf60208a029. View

13.

Venkatesh S, Dayanand Reddy G, Reddy Y, Sathyavathy D, Reddy B . Effect of Helicteres isora root extracts on glucose tolerance in glucose-induced hyperglycemic rats. Fitoterapia. 2004; 75(3-4):364-7. DOI: 10.1016/j.fitote.2003.12.025. View

14.

Singh R, Murthy K, Jayaprakasha G . Studies on the antioxidant activity of pomegranate (Punica granatum) peel and seed extracts using in vitro models. J Agric Food Chem. 2002; 50(1):81-6. DOI: 10.1021/jf010865b. View

15.

Noreen Y, Perera P, Bohlin L . Two new isoflavones from Ceiba pentandra and their effect on cyclooxygenase-catalyzed prostaglandin biosynthesis. J Nat Prod. 1998; 61(1):8-12. DOI: 10.1021/np970198+. View

16.

Ueda H, Kaneda N, Kawanishi K, Alves S, Moriyasu M . A new isoflavone glycoside from Ceiba pentandra (L.) Gaertner. Chem Pharm Bull (Tokyo). 2002; 50(3):403-4. DOI: 10.1248/cpb.50.403. View

17.

Ladeji O, Omekarah I, Solomon M . Hypoglycemic properties of aqueous bark extract of Ceiba pentandra in streptozotocin-induced diabetic rats. J Ethnopharmacol. 2003; 84(2-3):139-42. DOI: 10.1016/s0378-8741(02)00321-5. View

18.

Klein S, Cohen G, Cederbaum A . Production of formaldehyde during metabolism of dimethyl sulfoxide by hydroxyl radical generating systems. Biochemistry. 1981; 20(21):6006-12. DOI: 10.1021/bi00524a013. View

19.

Guo Q, Zhao B, Li M, Shen S, Xin W . Studies on protective mechanisms of four components of green tea polyphenols against lipid peroxidation in synaptosomes. Biochim Biophys Acta. 1996; 1304(3):210-22. DOI: 10.1016/s0005-2760(96)00122-1. View

20.

Zou Y, Lu Y, Wei D . Antioxidant activity of a flavonoid-rich extract of Hypericum perforatum L. in vitro. J Agric Food Chem. 2004; 52(16):5032-9. DOI: 10.1021/jf049571r. View