Potential Clinical Applications of Bimodal PET-MRI or SPECT-MRI Agents

Overview

Journal J Labelled Comp Radiopharm

Specialties Nuclear Medicine
Pharmacology
Pharmacy
Radiology

Date 2014 Jan 8

PMID 24395384

Citations 15

Authors

Rafael T M de Rosales

Affiliations

Soon will be listed here.

Abstract

The introduction to the clinic of positron emission tomography-magnetic resonance imaging scanners opens up the possibility to evaluate the real potential of bimodal imaging agents. In this mini-review, the limitations in the design and applications of these materials are summarised and the unique properties that may result in real clinical applications outlined.

Citing Articles

Radiolabeled iron oxide nanoparticles functionalized with PSMA/BN ligands for dual-targeting of prostate cancer.

Bajwa D, Salvanou E, Theodosiou M, Koutsikou T, Efthimiadou E, Bouziotis P Front Nucl Med. 2024; 3:1184309.

PMID: 39380961 PMC: 11460297. DOI: 10.3389/fnume.2023.1184309.

The use of PET/MRI in radiotherapy.

Yan Q, Yan X, Yang X, Li S, Song J Insights Imaging. 2024; 15(1):63.

PMID: 38411742 PMC: 10899128. DOI: 10.1186/s13244-024-01627-6.

Microfluidic Fabrication of Gadolinium-Doped Hydroxyapatite for Theragnostic Applications.

Somoza M, Rial R, Liu Z, Llovo I, Reis R, Mosqueira J Nanomaterials (Basel). 2023; 13(3).

PMID: 36770462 PMC: 9921701. DOI: 10.3390/nano13030501.

Nanoparticles and Radioisotopes: A Long Story in a Nutshell.

Poletto G, Evangelista L, Venturini F, Gramegna F, Seno F, Moro S Pharmaceutics. 2022; 14(10).

PMID: 36297457 PMC: 9612364. DOI: 10.3390/pharmaceutics14102024.

Radiolabeled PET/MRI Nanoparticles for Tumor Imaging.

Forte E, Fiorenza D, Torino E, Costagliola di Polidoro A, Cavaliere C, Netti P J Clin Med. 2020; 9(1).

PMID: 31905769 PMC: 7019574. DOI: 10.3390/jcm9010089.

References

Yang M, Cheng K, Qi S, Liu H, Jiang Y, Jiang H . Affibody modified and radiolabeled gold-iron oxide hetero-nanostructures for tumor PET, optical and MR imaging. Biomaterials. 2013; 34(11):2796-806. PMC: 3563754. DOI: 10.1016/j.biomaterials.2013.01.014. View

Glaus C, Rossin R, Welch M, Bao G . In vivo evaluation of (64)Cu-labeled magnetic nanoparticles as a dual-modality PET/MR imaging agent. Bioconjug Chem. 2010; 21(4):715-22. PMC: 2865436. DOI: 10.1021/bc900511j. View

Frullano L, Catana C, Benner T, Sherry A, Caravan P . Bimodal MR-PET agent for quantitative pH imaging. Angew Chem Int Ed Engl. 2010; 49(13):2382-4. PMC: 2869217. DOI: 10.1002/anie.201000075. View

Torres Martin de Rosales R, Tavare R, Paul R, Jauregui-Osoro M, Protti A, Glaria A . Synthesis of 64Cu(II)-bis(dithiocarbamatebisphosphonate) and its conjugation with superparamagnetic iron oxide nanoparticles: in vivo evaluation as dual-modality PET-MRI agent. Angew Chem Int Ed Engl. 2011; 50(24):5509-13. PMC: 3179845. DOI: 10.1002/anie.201007894. View

Aime S, Cabella C, Colombatto S, Crich S, Gianolio E, Maggioni F . Insights into the use of paramagnetic Gd(III) complexes in MR-molecular imaging investigations. J Magn Reson Imaging. 2002; 16(4):394-406. DOI: 10.1002/jmri.10180. View

Choi J, Park J, Nah H, Woo S, Oh J, Kim K . A hybrid nanoparticle probe for dual-modality positron emission tomography and magnetic resonance imaging. Angew Chem Int Ed Engl. 2008; 47(33):6259-62. DOI: 10.1002/anie.200801369. View

Lee H, Li Z, Chen K, Hsu A, Xu C, Xie J . PET/MRI dual-modality tumor imaging using arginine-glycine-aspartic (RGD)-conjugated radiolabeled iron oxide nanoparticles. J Nucl Med. 2008; 49(8):1371-9. DOI: 10.2967/jnumed.108.051243. View

Gianolio E, Maciocco L, Imperio D, Giovenzana G, Simonelli F, Abbas K . Dual MRI-SPECT agent for pH-mapping. Chem Commun (Camb). 2010; 47(5):1539-41. DOI: 10.1039/c0cc03554h. View

Herzog H . PET/MRI: challenges, solutions and perspectives. Z Med Phys. 2012; 22(4):281-98. DOI: 10.1016/j.zemedi.2012.07.003. View

10.

Torres Martin de Rosales R, Tavare R, Glaria A, Varma G, Protti A, Blower P . (⁹⁹m)Tc-bisphosphonate-iron oxide nanoparticle conjugates for dual-modality biomedical imaging. Bioconjug Chem. 2011; 22(3):455-65. PMC: 6205601. DOI: 10.1021/bc100483k. View

11.

Wunderbaldinger P, Josephson L, Bremer C, Moore A, Weissleder R . Detection of lymph node metastases by contrast-enhanced MRI in an experimental model. Magn Reson Med. 2002; 47(2):292-7. DOI: 10.1002/mrm.10068. View

12.

Judenhofer M, Wehrl H, Newport D, Catana C, Siegel S, Becker M . Simultaneous PET-MRI: a new approach for functional and morphological imaging. Nat Med. 2008; 14(4):459-65. DOI: 10.1038/nm1700. View

13.

Devaraj N, Keliher E, Thurber G, Nahrendorf M, Weissleder R . 18F labeled nanoparticles for in vivo PET-CT imaging. Bioconjug Chem. 2009; 20(2):397-401. PMC: 2644737. DOI: 10.1021/bc8004649. View

14.

Lewin M, Carlesso N, Tung C, Tang X, Cory D, Scadden D . Tat peptide-derivatized magnetic nanoparticles allow in vivo tracking and recovery of progenitor cells. Nat Biotechnol. 2000; 18(4):410-4. DOI: 10.1038/74464. View

15.

Newell K, Franchi A, Pouyssegur J, Tannock I . Studies with glycolysis-deficient cells suggest that production of lactic acid is not the only cause of tumor acidity. Proc Natl Acad Sci U S A. 1993; 90(3):1127-31. PMC: 45824. DOI: 10.1073/pnas.90.3.1127. View

16.

Nahrendorf M, Zhang H, Hembrador S, Panizzi P, Sosnovik D, Aikawa E . Nanoparticle PET-CT imaging of macrophages in inflammatory atherosclerosis. Circulation. 2007; 117(3):379-87. PMC: 2663426. DOI: 10.1161/CIRCULATIONAHA.107.741181. View

17.

Poulin E, Lebel R, Croteau E, Blanchette M, Tremblay L, Lecomte R . Conversion of arterial input functions for dual pharmacokinetic modeling using Gd-DTPA/MRI and 18F-FDG/PET. Magn Reson Med. 2012; 69(3):781-92. DOI: 10.1002/mrm.24318. View

18.

Harisinghani M, Barentsz J, Hahn P, Deserno W, Tabatabaei S, van de Kaa C . Noninvasive detection of clinically occult lymph-node metastases in prostate cancer. N Engl J Med. 2003; 348(25):2491-9. DOI: 10.1056/NEJMoa022749. View

19.

Uppal R, Catana C, Ay I, Benner T, Sorensen A, Caravan P . Bimodal thrombus imaging: simultaneous PET/MR imaging with a fibrin-targeted dual PET/MR probe--feasibility study in rat model. Radiology. 2010; 258(3):812-20. PMC: 3042637. DOI: 10.1148/radiol.10100881. View

20.

Uppal R, Ciesienski K, Chonde D, Loving G, Caravan P . Discrete bimodal probes for thrombus imaging. J Am Chem Soc. 2012; 134(26):10799-802. PMC: 3397236. DOI: 10.1021/ja3045635. View