Targeting a C-MYC G-quadruplex DNA with a Fragment Library

Overview

Journal Chem Commun (Camb)

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2014 Jan 8

PMID 24394582

Citations 25

Authors

Hamid R Nasiri

Neil M Bell

Keith I E McLuckie

Jarmila Husby

Chris Abell

Stephen Neidle

Shankar Balasubramanian

Affiliations

Soon will be listed here.

Abstract

We report here on the screening of a fragment library against a G-quadruplex element in the human c-MYC promoter. The ten fragment hits had significant concordance between a biophysical assay, in silico modelling and c-MYC expression inhibition, highlighting the feasibility of applying a fragment-based approach to the targeting of a quadruplex nucleic acid.

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