In Vitro Models of the Metastatic Cascade: from Local Invasion to Extravasation

Overview

Journal Drug Discov Today

Specialty Pharmacology

Date 2013 Dec 24

PMID 24361339

Citations 32

Authors

S Bersini

J S Jeon

Matteo Moretti

R D Kamm

Affiliations

Soon will be listed here.

Abstract

A crucial event in the metastatic cascade is the extravasation of circulating cancer cells from blood capillaries to the surrounding tissues. The past 5 years have been characterized by a significant evolution in the development of in vitro extravasation models, which moved from traditional transmigration chambers to more sophisticated microfluidic devices, enabling the study of complex cell-cell and cell-matrix interactions in multicellular, controlled environments. These advanced assays could be applied to screen easily and rapidly a broad spectrum of molecules inhibiting cancer cell endothelial adhesion and extravasation, thus contributing to the design of more focused in vivo tests.

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