Cellular MicroRNA MiR-181b Inhibits Replication of Mink Enteritis Virus by Repression of Non-structural Protein 1 Translation

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2013 Dec 19

PMID 24349084

Citations 10

Authors

Jia-Zeng Sun

Jigui Wang

Daoli Yuan

Shuang Wang

Zhili Li

Bao Yi

Yaping Mao

Qiang Hou

Weiquan Liu

Affiliations

Soon will be listed here.

Abstract

Mink enteritis virus (MEV) is one of the most important viral pathogens in the mink industry. Recent studies have showed that microRNAs (miRNAs), small noncoding RNAs of length ranging from 18-23 nucleotides (nt) participate in host-pathogen interaction networks; however, whether or not miRNAs are involved in MEV infection has not been reported. Our study revealed that miRNA miR-181b inhibited replication of MEV in the feline kidney (F81) cell line by targeting the MEV non-structural protein 1 (NS1) messenger RNA (mRNA) coding region, resulting in NS1 translational repression, while MEV infection reduced miR-181b expression. This is the first description of cellular miRNAs modulating MEV infection in F81 cells, providing further insight into the mechanisms of viral infection, and may be useful in development of naturally-occurring miRNAs antiviral strategies.

Citing Articles

Development of an Immunochromatographic Strip for Rapid Detection of Mink Enteritis Virus.

Lin P, Wang J, Song S, Cheng Y, Yi L, Cheng S Front Microbiol. 2022; 13:839320.

PMID: 35356522 PMC: 8959666. DOI: 10.3389/fmicb.2022.839320.

Virulent duck enteritis virus infected DEF cells generate a unique pattern of viral microRNAs and a novel set of host microRNAs.

Wu X, Jia R, Zhou J, Wang M, Chen S, Liu M BMC Vet Res. 2018; 14(1):144.

PMID: 29704894 PMC: 5923184. DOI: 10.1186/s12917-018-1468-2.

Mini Review: Circular RNAs as Potential Clinical Biomarkers for Disorders in the Central Nervous System.

Lu D, Xu A Front Genet. 2016; 7:53.

PMID: 27092176 PMC: 4821851. DOI: 10.3389/fgene.2016.00053.

Comparison of biological and genomic characteristics between a newly isolated mink enteritis parvovirus MEV-LHV and an attenuated strain MEV-L.

Mao Y, Wang J, Hou Q, Xi J, Zhang X, Bian D Virus Genes. 2016; 52(3):388-96.

PMID: 26993137 DOI: 10.1007/s11262-016-1314-1.

Possible involvement of miRNAs in tropism of Parvovirus B19.

Anbarlou A, AkhavanRahnama M, Atashi A, Soleimani M, Arefian E, Gallinella G Mol Biol Rep. 2016; 43(3):175-81.

PMID: 26878856 DOI: 10.1007/s11033-016-3952-8.

References

Yang C, Yue J, Fan M, Pfeffer L . IFN induces miR-21 through a signal transducer and activator of transcription 3-dependent pathway as a suppressive negative feedback on IFN-induced apoptosis. Cancer Res. 2010; 70(20):8108-16. PMC: 3014825. DOI: 10.1158/0008-5472.CAN-10-2579. View

Wang J, Cheng S, Yi L, Cheng Y, Yang S, Xu H . Evidence for natural recombination between mink enteritis virus and canine parvovirus. Virol J. 2012; 9:252. PMC: 3495801. DOI: 10.1186/1743-422X-9-252. View

Wang B, Li W, Guo K, Xiao Y, Wang Y, Fan J . miR-181b promotes hepatic stellate cells proliferation by targeting p27 and is elevated in the serum of cirrhosis patients. Biochem Biophys Res Commun. 2012; 421(1):4-8. DOI: 10.1016/j.bbrc.2012.03.025. View

Cotmore S, Tattersall P . An asymmetric nucleotide in the parvoviral 3' hairpin directs segregation of a single active origin of DNA replication. EMBO J. 1994; 13(17):4145-52. PMC: 395337. DOI: 10.1002/j.1460-2075.1994.tb06732.x. View

Bartel D . MicroRNAs: genomics, biogenesis, mechanism, and function. Cell. 2004; 116(2):281-97. DOI: 10.1016/s0092-8674(04)00045-5. View

Djuranovic S, Nahvi A, Green R . miRNA-mediated gene silencing by translational repression followed by mRNA deadenylation and decay. Science. 2012; 336(6078):237-40. PMC: 3971879. DOI: 10.1126/science.1215691. View

Beard C, St Amand J, Astell C . Transient expression of B19 parvovirus gene products in COS-7 cells transfected with B19-SV40 hybrid vectors. Virology. 1989; 172(2):659-64. DOI: 10.1016/0042-6822(89)90211-0. View

L Bookout A, Cummins C, Mangelsdorf D, Pesola J, Kramer M . High-throughput real-time quantitative reverse transcription PCR. Curr Protoc Mol Biol. 2008; Chapter 15:Unit 15.8. DOI: 10.1002/0471142727.mb1508s73. View

Doerig C, Hirt B, Antonietti J, Beard P . Nonstructural protein of parvoviruses B19 and minute virus of mice controls transcription. J Virol. 1990; 64(1):387-96. PMC: 249113. DOI: 10.1128/JVI.64.1.387-396.1990. View

10.

Pontius J, Mullikin J, Smith D, Lindblad-Toh K, Gnerre S, Clamp M . Initial sequence and comparative analysis of the cat genome. Genome Res. 2007; 17(11):1675-89. PMC: 2045150. DOI: 10.1101/gr.6380007. View

11.

Ahluwalia J, Khan S, Soni K, Rawat P, Gupta A, Hariharan M . Human cellular microRNA hsa-miR-29a interferes with viral nef protein expression and HIV-1 replication. Retrovirology. 2008; 5:117. PMC: 2635386. DOI: 10.1186/1742-4690-5-117. View

12.

Zeng Y, Yi R, Cullen B . MicroRNAs and small interfering RNAs can inhibit mRNA expression by similar mechanisms. Proc Natl Acad Sci U S A. 2003; 100(17):9779-84. PMC: 187842. DOI: 10.1073/pnas.1630797100. View

13.

Grey F, Tirabassi R, Meyers H, Wu G, McWeeney S, Hook L . A viral microRNA down-regulates multiple cell cycle genes through mRNA 5'UTRs. PLoS Pathog. 2010; 6(6):e1000967. PMC: 2891821. DOI: 10.1371/journal.ppat.1000967. View

14.

Tompkins S, Lo C, Tumpey T, Epstein S . Protection against lethal influenza virus challenge by RNA interference in vivo. Proc Natl Acad Sci U S A. 2004; 101(23):8682-6. PMC: 423255. DOI: 10.1073/pnas.0402630101. View

15.

Palliser D, Chowdhury D, Wang Q, Lee S, Bronson R, Knipe D . An siRNA-based microbicide protects mice from lethal herpes simplex virus 2 infection. Nature. 2005; 439(7072):89-94. DOI: 10.1038/nature04263. View

16.

Bazzini A, Lee M, Giraldez A . Ribosome profiling shows that miR-430 reduces translation before causing mRNA decay in zebrafish. Science. 2012; 336(6078):233-7. PMC: 3547538. DOI: 10.1126/science.1215704. View

17.

Song L, Liu H, Gao S, Jiang W, Huang W . Cellular microRNAs inhibit replication of the H1N1 influenza A virus in infected cells. J Virol. 2010; 84(17):8849-60. PMC: 2919005. DOI: 10.1128/JVI.00456-10. View

18.

WILSON G, Jindal H, Yeung D, Chen W, Astell C . Expression of minute virus of mice major nonstructural protein in insect cells: purification and identification of ATPase and helicase activities. Virology. 1991; 185(1):90-8. DOI: 10.1016/0042-6822(91)90757-3. View

19.

Horiuchi M, Mochizuki M, Ishiguro N, Nagasawa H, Shinagawa M . Epitope mapping of a monoclonal antibody specific to feline panleukopenia virus and mink enteritis virus. J Vet Med Sci. 1997; 59(2):133-6. DOI: 10.1292/jvms.59.133. View

20.

Otsuka M, Jing Q, Georgel P, New L, Chen J, Mols J . Hypersusceptibility to vesicular stomatitis virus infection in Dicer1-deficient mice is due to impaired miR24 and miR93 expression. Immunity. 2007; 27(1):123-34. DOI: 10.1016/j.immuni.2007.05.014. View