Concepts of Tissue Injury and Cell Death in Inflammation: a Historical Perspective

Overview

Journal Nat Rev Immunol

Specialty Allergy & Immunology

Date 2013 Dec 17

PMID 24336099

Citations 108

Authors

David Wallach

Tae-Bong Kang

Andrew Kovalenko

Affiliations

Soon will be listed here.

Abstract

Emerging evidence indicates that the molecular mechanisms of cell death have regulatory roles in inflammation and that the molecular changes that are associated with different forms of cell death affect the course of inflammation in different ways. In this Timeline article, we discuss how our understanding of the mechanisms and functional roles of tissue injury and cell death in inflammation has evolved on the basis of almost two centuries of study. We describe how such ideas have led to our current models of cell death and inflammation, and we highlight the remaining gaps in our knowledge of the subject.

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