Ferroptosis: a Promising Candidate for Exosome-mediated Regulation in Different Diseases

Overview

Journal Cell Commun Signal

Publisher Biomed Central

Specialties Biochemistry
Cell Biology

Date 2024 Jan 3

PMID 38166927

Authors

Limin Liu

Yulin Ye

Rui Lin

Tianyu Liu

Sinan Wang

Zelin Feng

Xiaoli Wang

Hailong Cao

Xin Chen

Junming Miao

Yifei Liu

Kui Jiang

Zhibo Han

Zongjin Li

Xiaocang Cao

Affiliations

Soon will be listed here.

Abstract

Ferroptosis is a newly discovered form of cell death that is featured in a wide range of diseases. Exosome therapy is a promising therapeutic option that has attracted much attention due to its low immunogenicity, low toxicity, and ability to penetrate biological barriers. In addition, emerging evidence indicates that exosomes possess the ability to modulate the progression of diverse diseases by regulating ferroptosis in damaged cells. Hence, the mechanism by which cell-derived and noncellular-derived exosomes target ferroptosis in different diseases through the system Xc/GSH/GPX4 axis, NAD(P)H/FSP1/CoQ10 axis, iron metabolism pathway and lipid metabolism pathway associated with ferroptosis, as well as its applications in liver disease, neurological diseases, lung injury, heart injury, cancer and other diseases, are summarized here. Additionally, the role of exosome-regulated ferroptosis as an emerging repair mechanism for damaged tissues and cells is also discussed, and this is expected to be a promising treatment direction for various diseases in the future. Video Abstract.

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