Increased Expression of the Long Non-coding RNA UCA1 in Tongue Squamous Cell Carcinomas: a Possible Correlation with Cancer Metastasis

Overview

Journal Oral Surg Oral Med Oral Pathol Oral Radiol

Publisher Elsevier

Specialties Dentistry
General Surgery

Date 2013 Dec 17

PMID 24332332

Citations 81

Authors

Zhengyu Fang

Lamei Wu

Luo Wang

Yang Yang

Yusheng Meng

Hongyu Yang

Affiliations

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Abstract

Objective: The aim of this study was to examine the expression of several cancer-related long non-coding RNAs (lncRNAs) in patients with tongue squamous cell carcinoma (TSCC) and to explore its clinical significance.

Study Design: A total of 94 TSCC tissue specimens and matched adjacent normal tissue specimens were collected from patients undergoing surgery for TSCC. Differences in the expression of cancer-related lncRNAs were examined via quantitative reverse transcriptase polymerase chain reaction. WST-1 assay and transwell migration assay were carried out to estimate the proliferation and migration abilities of TSCC cells with different expression levels of urothelial cancer-associated 1 (UCA1) lncRNA.

Results: The expression levels of lncRNA UCA1 were significantly elevated in TSCC tissues (P < .0001) and were statistically correlated with lymph node metastasis (P = .0371). Over-expression of UCA1 lncRNA could promote metastatic but not proliferation ability of TSCC cells.

Conclusions: Expression of UCA1 lncRNA was enhanced in TSCCs and may play a role in tumor metastasis.

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