The Role of LncRNA Crosstalk in Leading Cancer Metastasis of Head and Neck Squamous Cell Carcinoma

Overview

Journal Front Oncol

Specialty Oncology

Date 2020 Oct 30

PMID 33123473

Citations 16

Authors

Yu Wang

Sinan Wang

Yu Ren

Xuan Zhou

Affiliations

Soon will be listed here.

Abstract

Head and neck squamous cell carcinoma (HNSCC) is the sixth most common type of human malignancy. For decades, research into HNSCC invasion and metastasis has been dedicated to the study of protein-coding genes. Along with whole-genome and transcriptome sequencing development, long non-coding RNA (lncRNA) has attracted greater attention. Compelling evidence has proven the critical role of lncRNAs in the occurrence and development of HNSCC by means of epigenetic modifications, regulation of gene transcription, and post-transcription level. More importantly, crosstalk between lncRNAs and microRNAs was recently proven to regulate HNSCC metastasis through EMT modification. Based on these, this review summarizes the critical roles of lncRNAs in HNSCC metastasis and the crosstalk between lncRNAs and microRNAs as well as the detailed regulatory mechanism of the interaction. Thus, a deeper understanding of the lncRNA network in cancer metastasis is finally uncovered in order to provide a rationale and innovative concepts toward new therapeutic strategies for the highly metastatic HNSCC.

Citing Articles

Epithelial‑derived head and neck squamous tumourigenesis (Review).

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Ferroptosis in head and neck squamous cell carcinoma: from pathogenesis to treatment.

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