Meta-selective C-H Functionalization Using a Nitrile-based Directing Group and Cleavable Si-tether

Overview

Journal J Am Chem Soc

Publisher American Chemical Society

Specialty Chemistry

Date 2013 Dec 12

PMID 24325399

Citations 37

Authors

Sunggi Lee

Hyelee Lee

Kian L Tan

Affiliations

Soon will be listed here.

Abstract

A nitrile-based template that enables meta-selective C-H bond functionalization was developed. The template is applicable to a range of substituted arenes and tolerates a variety of functional groups. The directing group uses a silicon atom for attachment, allowing for a facile introduction/deprotection strategy increasing the synthetic practicality of this template.

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