Rikkunshito, a Japanese Kampo Medicine, Ameliorates Decreased Feeding Behavior Via Ghrelin and Serotonin 2B Receptor Signaling in a Novelty Stress Murine Model

Overview

Journal Biomed Res Int

Publisher Wiley

Specialties Biomedical Engineering
Biotechnology
General Medicine

Date 2013 Nov 30

PMID 24288687

Citations 16

Authors

Chihiro Yamada

Yayoi Saegusa

Koji Nakagawa

Shunsuke Ohnishi

Shuichi Muto

Miwa Nahata

Chiharu Sadakane

Tomohisa Hattori

Naoya Sakamoto

Hiroshi Takeda

Affiliations

Soon will be listed here.

Abstract

We investigated the effects of rikkunshito (RKT), a ghrelin signal enhancer, on the decrease in food intake after exposure to novelty stress in mice. RKT administration (500 mg/kg, per os) improved the decrease in 6 h cumulative food intake. In control mice, the plasma acylated ghrelin levels significantly increased by 24 h fasting. In contrast, the acylated ghrelin levels did not increase by fasting in mice exposed to the novelty stress. RKT administration to the novelty stress mice showed a significant increase in the acylated ghrelin levels compared with that in the distilled-water-treated control mice. Food intake after administering serotonin 2B (5-HT(2B)) receptor antagonists was evaluated to clarify the role of 5-HT(2B) receptor activation in the decrease in feeding behavior after novelty stress. SB215505 and SB204741, 5-HT(2B) receptor antagonists, significantly improved the decrease in food intake after exposure to novelty stress. A component of RKT, isoliquiritigenin, prevented the decrease in 6 h cumulative food intake. Isoliquiritigenin showed 5-HT(2B) receptor antagonistic activity in vitro. In conclusion, the results suggested that RKT improves the decrease in food intake after novelty stress probably via 5-HT(2B) receptor antagonism of isoliquiritigenin contained in RKT.

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