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» Authors » Chiharu Sadakane

Chiharu Sadakane

Explore the profile of Chiharu Sadakane including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 29
Citations 514
Followers 0
Related Specialties
Biochemistry
Endocrinology
General Medicine
Top 10 Co-Authors
Tomohisa Hattori
Hiroshi Takeda
Yayoi Saegusa
Miwa Nahata
Masahiro Asaka
Koji Nakagawa
Shuichi Muto
Shunsuke Ohnishi
Junichi Koseki
Shuichi Takeda
Published In
Biol Pharm Bull
PLoS One
Clin Exp Nephrol
Endocrinology
Psychoneuroendocrinology
Affiliations
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Recent Articles
1.
Exploration of serum biomarkers for predicting the response to Inchinkoto (ICKT), a Japanese traditional herbal medicine
Uji M, Yokoyama Y, Ohbuchi K, Tsuchiya K, Sadakane C, Shimobori C, et al.
Metabolomics . 2019 Aug; 13(12):155. PMID: 31375927
Introduction: In patients with obstructive jaundice, biliary drainage sometimes fails to result in improvement. A pharmaceutical-grade choleretic herbal medicine, Inchinkoto (ICKT), has been proposed to exert auxiliary effects on biliary...
2.
Data on metabolic profiling of healthy human subjects' plasma before and after administration of the Japanese Kampo medicine maoto
Kitagawa H, Ohbuchi K, Munekage M, Fujisawa K, Kawanishi Y, Namikawa T, et al.
Data Brief . 2019 Jan; 22:359-364. PMID: 30596132
This data article contains the data on metabolic profiling of healthy human subjects' plasma before and after administration of the Japanese Kampo medicine maoto. Four healthy human subjects were recruited....
3.
Phenotyping analysis of the Japanese Kampo medicine maoto in healthy human subjects using wide-targeted plasma metabolomics
Kitagawa H, Ohbuchi K, Munekage M, Fujisawa K, Kawanishi Y, Namikawa T, et al.
J Pharm Biomed Anal . 2018 Oct; 164:119-127. PMID: 30368117
Traditional herbal medicine (THM) consists of a vast number of compounds that exert pharmacological effects throughout the body. Comprehensive phenotyping analysis using omics is essential for understanding the nature of...
4.
Psychological stress in aged female mice causes acute hypophagia independent of central serotonin 2C receptor activation
Matsumoto C, Yamada C, Sadakane C, Nahata M, Hattori T, Takeda H
PLoS One . 2017 Nov; 12(11):e0187937. PMID: 29125864
Sex differences exist in the activation of the hypothalamic-pituitary-adrenal axis following exposure to stress, and the stress response is further affected by aging. This study was conducted to elucidate the...
5.
CRF receptor 1 antagonism and brain distribution of active components contribute to the ameliorative effect of rikkunshito on stress-induced anorexia
Mogami S, Sadakane C, Nahata M, Mizuhara Y, Yamada C, Hattori T, et al.
Sci Rep . 2016 Jun; 6:27516. PMID: 27273195
Rikkunshito (RKT), a Kampo medicine, has been reported to show an ameliorative effect on sustained hypophagia after novelty stress exposure in aged mice through serotonin 2C receptor (5-HT2CR) antagonism. We...
6.
Influence of Aging and Gender Differences on Feeding Behavior and Ghrelin-Related Factors during Social Isolation in Mice
Yamada C, Saegusa Y, Nahata M, Sadakane C, Hattori T, Takeda H
PLoS One . 2015 Oct; 10(10):e0140094. PMID: 26448274
Psychological stress due to social isolation is known to cause abnormal feeding behaviors, but the influences of gender and aging on subchronic stress-induced changes in feeding behaviors are unknown. Thus,...
7.
Pharmacokinetic Profiles of Active Components After Oral Administration of a Kampo Medicine, Shakuyakukanzoto, to Healthy Adult Japanese Volunteers
Sadakane C, Watanabe J, Fukutake M, Nisimura H, Maemura K, Kase Y, et al.
J Pharm Sci . 2015 Jul; 104(11):3952-3959. PMID: 26211516
Shakuyakukanzoto (SKT), a traditional Japanese (Kampo) medicine, has been used by patients with muscle cramps and abdominal pains. In this trial, we analyzed plasma concentrations of active components after SKT...
8.
Pharmacokinetic Profiles of Active Ingredients and Its Metabolites Derived from Rikkunshito, a Ghrelin Enhancer, in Healthy Japanese Volunteers: A Cross-Over, Randomized Study
Kitagawa H, Munekage M, Matsumoto T, Sadakane C, Fukutake M, Aoki K, et al.
PLoS One . 2015 Jul; 10(7):e0133159. PMID: 26186592
Background: Rikkunshito, a traditional Japanese (Kampo) medicine, has been used to treat upper gastrointestinal disorders such as functional dyspepsia and gastroesophageal reflux. This study investigated the exposure and pharmacokinetics of...
9.
Serotonin 2C receptor contributes to gender differences in stress-induced hypophagia in aged mice
Yamada C, Sadakane C, Nahata M, Saegusa Y, Nakagawa K, Okubo N, et al.
Psychoneuroendocrinology . 2015 Mar; 55:81-93. PMID: 25732068
The combination of depression and anorexia may influence morbidity and progressive physical disability in the elderly. Gender differences exist in hypothalamic-pituitary-adrenal axis activation following stress exposure. The objective of this...
10.
Rikkunshito, a Japanese kampo medicine, ameliorates decreased feeding behavior via ghrelin and serotonin 2B receptor signaling in a novelty stress murine model
Yamada C, Saegusa Y, Nakagawa K, Ohnishi S, Muto S, Nahata M, et al.
Biomed Res Int . 2013 Nov; 2013:792940. PMID: 24288687
We investigated the effects of rikkunshito (RKT), a ghrelin signal enhancer, on the decrease in food intake after exposure to novelty stress in mice. RKT administration (500 mg/kg, per os)...