Involvement of Ghrelin Dynamics in Stress-Induced Eating Disorder: Effects of Sex and Aging

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2021 Nov 13

PMID 34769125

Citations 3

Authors

Chihiro Yamada

Affiliations

Soon will be listed here.

Abstract

Stress, a factor that affects appetite in our daily lives, enhances or suppresses appetite and changes palatability. However, so far, the mechanisms underlying the link between stress and eating have not been fully elucidated. Among the peripherally produced appetite-related peptides, ghrelin is the only orexigenic peptide, and abnormalities in the dynamics and reactivity of this peptide are involved in appetite abnormalities in various diseases and psychological states. This review presents an overview of the research results of studies evaluating the effects of various stresses on appetite. The first half of this review describes the relationship between appetite and stress, and the second half describes the relationship between the appetite-promoting peptide ghrelin and stress. The effects of sex differences and aging under stress on appetite are also described.

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References

Kageyama K, Akimoto K, Yamagata S, Sugiyama A, Murasawa S, Watanuki Y . Dexamethasone stimulates the expression of ghrelin and its receptor in rat hypothalamic 4B cells. Regul Pept. 2011; 174(1-3):12-7. DOI: 10.1016/j.regpep.2011.11.003. View

Fiske A, Wetherell J, Gatz M . Depression in older adults. Annu Rev Clin Psychol. 2009; 5:363-89. PMC: 2852580. DOI: 10.1146/annurev.clinpsy.032408.153621. View

Lutter M, Sakata I, Osborne-Lawrence S, Rovinsky S, Anderson J, Jung S . The orexigenic hormone ghrelin defends against depressive symptoms of chronic stress. Nat Neurosci. 2008; 11(7):752-3. PMC: 2765052. DOI: 10.1038/nn.2139. View

Francesco V, Zamboni M, Zoico E, Mazzali G, Dioli A, Omizzolo F . Unbalanced serum leptin and ghrelin dynamics prolong postprandial satiety and inhibit hunger in healthy elderly: another reason for the "anorexia of aging". Am J Clin Nutr. 2006; 83(5):1149-52. DOI: 10.1093/ajcn/83.5.1149. View

Kobelt P, Tebbe J, Tjandra I, Stengel A, Bae H, Andresen V . CCK inhibits the orexigenic effect of peripheral ghrelin. Am J Physiol Regul Integr Comp Physiol. 2004; 288(3):R751-8. DOI: 10.1152/ajpregu.00094.2004. View

Harada Y, Takayama K, Ro S, Ochiai M, Noguchi M, Iizuka S . Urocortin1-induced anorexia is regulated by activation of the serotonin 2C receptor in the brain. Peptides. 2013; 51:139-44. DOI: 10.1016/j.peptides.2013.11.009. View

Kiessl G, Laessle R . Stress does not affect ghrelin secretion in obese and normal weight women. Eat Weight Disord. 2016; 22(1):79-84. DOI: 10.1007/s40519-016-0316-2. View

Perry 3rd H, Morley J, Horowitz M, Kaiser F, Miller D, Wittert G . Body composition and age in African-American and Caucasian women: relationship to plasma leptin levels. Metabolism. 1998; 46(12):1399-405. DOI: 10.1016/s0026-0495(97)90138-4. View

Shields G, Sazma M, McCullough A, Yonelinas A . The effects of acute stress on episodic memory: A meta-analysis and integrative review. Psychol Bull. 2017; 143(6):636-675. PMC: 5436944. DOI: 10.1037/bul0000100. View

10.

Nakayama S, Nishiyama M, Iwasaki Y, Shinahara M, Okada Y, Tsuda M . Corticotropin-releasing hormone (CRH) transgenic mice display hyperphagia with increased Agouti-related protein mRNA in the hypothalamic arcuate nucleus. Endocr J. 2011; 58(4):279-86. DOI: 10.1507/endocrj.k10e-370. View

11.

Haleem D . Investigations into the involvement of leptin in responses to stress. Behav Pharmacol. 2014; 25(5-6):384-97. DOI: 10.1097/FBP.0000000000000050. View

12.

Scott S, Graham-Engeland J, Engeland C, Smyth J, Almeida D, Katz M . The Effects of Stress on Cognitive Aging, Physiology and Emotion (ESCAPE) Project. BMC Psychiatry. 2015; 15:146. PMC: 4490700. DOI: 10.1186/s12888-015-0497-7. View

13.

de Mello Cruz A, Pinheiro G, Alves S, Ferreira G, Mendes M, Faria L . Behavioral effects of systemically administered MK-212 are prevented by ritanserin microinfusion into the basolateral amygdala of rats exposed to the elevated plus-maze. Psychopharmacology (Berl). 2005; 182(3):345-54. DOI: 10.1007/s00213-005-0108-2. View

14.

Seale J, Wood S, Atkinson H, Harbuz M, Lightman S . Gonadal steroid replacement reverses gonadectomy-induced changes in the corticosterone pulse profile and stress-induced hypothalamic-pituitary-adrenal axis activity of male and female rats. J Neuroendocrinol. 2005; 16(12):989-98. DOI: 10.1111/j.1365-2826.2004.01258.x. View

15.

Fujitsuka N, Asakawa A, Hayashi M, Sameshima M, Amitani H, Kojima S . Selective serotonin reuptake inhibitors modify physiological gastrointestinal motor activities via 5-HT2c receptor and acyl ghrelin. Biol Psychiatry. 2008; 65(9):748-59. DOI: 10.1016/j.biopsych.2008.10.031. View

16.

Aguilera G, Liu Y . The molecular physiology of CRH neurons. Front Neuroendocrinol. 2011; 33(1):67-84. PMC: 4341841. DOI: 10.1016/j.yfrne.2011.08.002. View

17.

Udden J, Bjorntorp P, Arner P, Barkeling B, Meurling L, Rossner S . Effects of glucocorticoids on leptin levels and eating behaviour in women. J Intern Med. 2003; 253(2):225-31. DOI: 10.1046/j.1365-2796.2003.01099.x. View

18.

Weiser M, Handa R . Estrogen impairs glucocorticoid dependent negative feedback on the hypothalamic-pituitary-adrenal axis via estrogen receptor alpha within the hypothalamus. Neuroscience. 2009; 159(2):883-95. PMC: 5837863. DOI: 10.1016/j.neuroscience.2008.12.058. View

19.

Nonogaki K . Ghrelin and feedback systems. Vitam Horm. 2007; 77:149-70. DOI: 10.1016/S0083-6729(06)77007-8. View

20.

Vilarrasa N, Vendrell J, Maravall J, Broch M, Estepa A, Megia A . Distribution and determinants of adiponectin, resistin and ghrelin in a randomly selected healthy population. Clin Endocrinol (Oxf). 2005; 63(3):329-35. DOI: 10.1111/j.1365-2265.2005.02346.x. View