Effects of Concentrated Arabinoxylan and β-glucan Compared with Refined Wheat and Whole Grain Rye on Glucose and Appetite in Subjects with the Metabolic Syndrome: a Randomized Study

Overview

Journal Eur J Clin Nutr

Specialty Nutritional Sciences

Date 2013 Nov 21

PMID 24253758

Citations 30

Authors

M L Hartvigsen

S Gregersen

H N Laerke

J J Holst

K E Bach Knudsen

K Hermansen

Affiliations

Soon will be listed here.

Abstract

Background/objectives: Several studies emphasise that arabinoxylan and β-glucan have more beneficial effects on glucose metabolism than low-dietary fibre (DF) meals. Less attention has been paid to the effects of concentrated DF compared with whole grain. We compared the effects of DF and whole grain on glucose, hormone responses and appetite in subjects with the metabolic syndrome (MetS).

Subjects/methods: Fifteen subjects with MetS participated in this acute, randomised, cross-over intervention study. The test breads provided 50 g of digestible carbohydrate: wheat bread with concentrated arabinoxylan (AX) or β-glucan (BG), rye bread with kernels (RK) and wheat bread (WB) as control. Blood samples were drawn for 270 min to determine glucose, insulin, glucagon-like peptide-1, glucose-dependent insulinotropic peptide (GIP) and ghrelin. Appetite score was addressed every 30 min. Ad libitum energy intake (EI) was measured 270 min after test meals.

Results: Compared with WB, BG and RK induced lower initial glycaemic responses (P<0.001), whereas AX only reduced the glucose peak value (P<0.001). RK reduced insulin (P<0.001) and GIP responses (P<0.001) compared with the other breads. BG lowered insulin responses more than AX (P<0.001). AX, BG and RK increased satiety feeling (P<0.001) more than WB, but did not differ significantly in terms of subsequent EI (P=0.089).

Conclusion: BG and RK had beneficial impact on the glucose response, whereas AX had only effect on the postprandial glucose peak. The impact of the AX bread was influenced by higher protein content. Whether the metabolic effects of the breads are still present to mixed meals remains to be tested.

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References

Garcia A, Otto B, Reich S, Weickert M, Steiniger J, Machowetz A . Arabinoxylan consumption decreases postprandial serum glucose, serum insulin and plasma total ghrelin response in subjects with impaired glucose tolerance. Eur J Clin Nutr. 2006; 61(3):334-41. DOI: 10.1038/sj.ejcn.1602525. View

Mohlig M, Koebnick C, Weickert M, Lueder W, Otto B, Steiniger J . Arabinoxylan-enriched meal increases serum ghrelin levels in healthy humans. Horm Metab Res. 2005; 37(5):303-8. DOI: 10.1055/s-2005-861474. View

Granfeldt Y, Liljeberg H, Drews A, Newman R, Bjorck I . Glucose and insulin responses to barley products: influence of food structure and amylose-amylopectin ratio. Am J Clin Nutr. 1994; 59(5):1075-82. DOI: 10.1093/ajcn/59.5.1075. View

Giacco R, Della Pepa G, Luongo D, Riccardi G . Whole grain intake in relation to body weight: from epidemiological evidence to clinical trials. Nutr Metab Cardiovasc Dis. 2011; 21(12):901-8. DOI: 10.1016/j.numecd.2011.07.003. View

Vitaglione P, Barone Lumaga R, Stanzione A, Scalfi L, Fogliano V . beta-Glucan-enriched bread reduces energy intake and modifies plasma ghrelin and peptide YY concentrations in the short term. Appetite. 2009; 53(3):338-44. DOI: 10.1016/j.appet.2009.07.013. View

Deacon C, Nauck M, Meier J, Hucking K, Holst J . Degradation of endogenous and exogenous gastric inhibitory polypeptide in healthy and in type 2 diabetic subjects as revealed using a new assay for the intact peptide. J Clin Endocrinol Metab. 2000; 85(10):3575-81. DOI: 10.1210/jcem.85.10.6855. View

Juntunen K, Laaksonen D, Autio K, Niskanen L, Holst J, Savolainen K . Structural differences between rye and wheat breads but not total fiber content may explain the lower postprandial insulin response to rye bread. Am J Clin Nutr. 2003; 78(5):957-64. DOI: 10.1093/ajcn/78.5.957. View

Hartvigsen M, Jeppesen P, Laerke H, Njabe E, Bach Knudsen K, Hermansen K . Concentrated arabinoxylan in wheat bread has beneficial effects as rye breads on glucose and changes in gene expressions in insulin-sensitive tissues of Zucker diabetic fatty (ZDF) rats. J Agric Food Chem. 2013; 61(21):5054-63. DOI: 10.1021/jf3043538. View

Juvonen K, Purhonen A, Salmenkallio-Marttila M, Lahteenmaki L, Laaksonen D, Herzig K . Viscosity of oat bran-enriched beverages influences gastrointestinal hormonal responses in healthy humans. J Nutr. 2009; 139(3):461-6. DOI: 10.3945/jn.108.099945. View

10.

Lu Z, Walker K, Muir J, ODea K . Arabinoxylan fibre improves metabolic control in people with Type II diabetes. Eur J Clin Nutr. 2004; 58(4):621-8. DOI: 10.1038/sj.ejcn.1601857. View

11.

Benini L, Castellani G, Brighenti F, Heaton K, Brentegani M, Casiraghi M . Gastric emptying of a solid meal is accelerated by the removal of dietary fibre naturally present in food. Gut. 1995; 36(6):825-30. PMC: 1382616. DOI: 10.1136/gut.36.6.825. View

12.

Wanders A, van den Borne J, de Graaf C, Hulshof T, Jonathan M, Kristensen M . Effects of dietary fibre on subjective appetite, energy intake and body weight: a systematic review of randomized controlled trials. Obes Rev. 2011; 12(9):724-39. DOI: 10.1111/j.1467-789X.2011.00895.x. View

13.

Beck E, Tosh S, Batterham M, Tapsell L, Huang X . Oat beta-glucan increases postprandial cholecystokinin levels, decreases insulin response and extends subjective satiety in overweight subjects. Mol Nutr Food Res. 2009; 53(10):1343-51. DOI: 10.1002/mnfr.200800343. View

14.

Rosen L, Ostman E, Bjorck I . Effects of cereal breakfasts on postprandial glucose, appetite regulation and voluntary energy intake at a subsequent standardized lunch; focusing on rye products. Nutr J. 2011; 10:7. PMC: 3031216. DOI: 10.1186/1475-2891-10-7. View

15.

Nazare J, Normand S, Oste Triantafyllou A, Brac de la Perriere A, Desage M, Laville M . Modulation of the postprandial phase by beta-glucan in overweight subjects: effects on glucose and insulin kinetics. Mol Nutr Food Res. 2008; 53(3):361-9. DOI: 10.1002/mnfr.200800023. View

16.

Rosen L, Silva L, Andersson U, Holm C, Ostman E, Bjorck I . Endosperm and whole grain rye breads are characterized by low post-prandial insulin response and a beneficial blood glucose profile. Nutr J. 2009; 8:42. PMC: 2761418. DOI: 10.1186/1475-2891-8-42. View

17.

Makelainen H, Anttila H, Sihvonen J, Hietanen R, Tahvonen R, Salminen E . The effect of beta-glucan on the glycemic and insulin index. Eur J Clin Nutr. 2006; 61(6):779-85. DOI: 10.1038/sj.ejcn.1602561. View

18.

Peters H, Boers H, Haddeman E, Melnikov S, Qvyjt F . No effect of added beta-glucan or of fructooligosaccharide on appetite or energy intake. Am J Clin Nutr. 2008; 89(1):58-63. DOI: 10.3945/ajcn.2008.26701. View

19.

Lejeune M, Westerterp K, Adam T, Luscombe-Marsh N, Westerterp-Plantenga M . Ghrelin and glucagon-like peptide 1 concentrations, 24-h satiety, and energy and substrate metabolism during a high-protein diet and measured in a respiration chamber. Am J Clin Nutr. 2006; 83(1):89-94. DOI: 10.1093/ajcn/83.1.89. View

20.

Alberti K, Zimmet P, Shaw J . The metabolic syndrome--a new worldwide definition. Lancet. 2005; 366(9491):1059-62. DOI: 10.1016/S0140-6736(05)67402-8. View