The Deleterious Role of Basophils in Systemic Lupus Erythematosus

Overview

Journal Curr Opin Immunol

Publisher Elsevier

Specialty Allergy & Immunology

Date 2013 Nov 12

PMID 24209595

Citations 14

Authors

Christophe Pellefigues

Nicolas Charles

Affiliations

Soon will be listed here.

Abstract

Systemic lupus erythematosus is a complex autoimmune disease of multifactorial origins. All compartments of the immune system appear to be affected, at least in some way, and to contribute to disease pathogenesis. Because of an escape from negative selection autoreactive T and B cells accumulate in SLE patients leading to the production of autoantibodies mainly raised against nuclear components and their subsequent deposition into target organs. We recently showed that basophils, in an IgE and IL-4 dependent manner, contribute to SLE pathogenesis by amplifying autoantibody production. Here, we summarize what we have learned about the deleterious role of basophils in lupus both in a mouse model and in SLE patients. We discuss which possible pathways could be involved in basophil activation and recruitment to secondary lymphoid organs during SLE, and how basophils may amplify autoantibody production.

Citing Articles

Basophils beyond allergic and parasitic diseases.

Poto R, Loffredo S, Marone G, Di Salvatore A, De Paulis A, Schroeder J Front Immunol. 2023; 14:1190034.

PMID: 37205111 PMC: 10185837. DOI: 10.3389/fimmu.2023.1190034.

Unraveling the Link between Interferon-α and Systemic Lupus Erythematosus: From the Molecular Mechanisms to Target Therapies.

Infante B, Mercuri S, Dello Strologo A, Franzin R, Catalano V, Troise D Int J Mol Sci. 2022; 23(24).

PMID: 36555640 PMC: 9783870. DOI: 10.3390/ijms232415998.

Analysis of Peripheral Blood Basophils in Pediatric Systemic Lupus Erythematosus.

Dossybayeva K, Bexeitov Y, Mukusheva Z, Almukhamedova Z, Assylbekova M, Abdukhakimova D Diagnostics (Basel). 2022; 12(7).

PMID: 35885605 PMC: 9317310. DOI: 10.3390/diagnostics12071701.

AMG853, A Bispecific Prostaglandin D Receptor 1 and 2 Antagonist, Dampens Basophil Activation and Related Lupus-Like Nephritis Activity in Lyn-Deficient Mice.

Pellefigues C, Tchen J, Saji C, Lamri Y, Charles N Front Immunol. 2022; 13:824686.

PMID: 35444641 PMC: 9014266. DOI: 10.3389/fimmu.2022.824686.

Role of the innate and adaptive immune responses in the pathogenesis of systemic lupus erythematosus.

Bolouri N, Akhtari M, Farhadi E, Mansouri R, Faezi S, Jamshidi A Inflamm Res. 2022; 71(5-6):537-554.

PMID: 35298669 DOI: 10.1007/s00011-022-01554-6.

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