Basophils As a Potential Marker of Lupus Nephritis by Flow Cytometry

Overview

Journal Future Sci OA

Specialty Biotechnology

Date 2021 May 28

PMID 34046192

Citations 2

Authors

Yanni Jiang

Jin Chen

Yi Zhao

Yi Liu

Hong Xu

Xianming Mo

Affiliations

Soon will be listed here.

Abstract

Objective: To establish a convenient and simple flow cytometry immunophenotyping panel to explore immune cellular alterations and potential cellular biomarkers in systemic lupus erythematosus.

Materials And Methods: This is a cross-sectional, case-control study including 60 patients with systemic lupus erythematosus and 20 sex- and age-matched healthy controls. A 14-color immunophenotyping panel was applied to detect proportions of circulating immune mononuclear cells, and comparisons between patients and healthy controls, and subgroups of patients, were performed. Correlations between cellular proportions and other parameters were investigated.

Results: After multivariate analysis, significantly decreased proportions of CD4CD8 T cells, natural killer cells and innate lymphoid cells were observed in patients compared with healthy controls. The proportions of basophils were decreased significantly in patients with lupus nephritis (LN) compared with those in patients without LN.

Conclusion: In the present study, we found that basophil proportions may be a biomarker of LN.

Citing Articles

Double-Negative T (DNT) Cells in Patients with Systemic Lupus Erythematosus.

Poddighe D, Dossybayeva K, Kozhakhmetov S, Rozenson R, Assylbekova M Biomedicines. 2024; 12(1).

PMID: 38255272 PMC: 10812956. DOI: 10.3390/biomedicines12010166.

Analysis of Peripheral Blood Basophils in Pediatric Systemic Lupus Erythematosus.

Dossybayeva K, Bexeitov Y, Mukusheva Z, Almukhamedova Z, Assylbekova M, Abdukhakimova D Diagnostics (Basel). 2022; 12(7).

PMID: 35885605 PMC: 9317310. DOI: 10.3390/diagnostics12071701.

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