An Alternative Pathway Through the Fenton Reaction for the Formation of Advanced Oxidation Protein Products, a New Class of Inflammatory Mediators

Overview

Journal Inflammation

Specialties Allergy & Immunology
Pathology

Date 2013 Nov 7

PMID 24193368

Citations 9

Authors

Guilherme Vargas Bochi

Vanessa Dorneles Torbitz

Lara Peruzzolo Cargnin

Jose Antonio Mainardi De Carvalho

Patricia Gomes

Rafael Noal Moresco

Affiliations

Soon will be listed here.

Abstract

The accumulation of advanced oxidation protein products (AOPPs) has been linked to several pathological conditions, and their levels are formed during oxidative stress as a result of reactions between plasma proteins and chlorinated oxidants produced by myeloperoxidase (MPO). However, it was suggested that the generation of this mediator of inflammation may also occur via an MPO-independent pathway. The aim of this study was to induce the formation of AOPPs in vitro through Fenton reaction and to investigate whether this generation could be counteracted by N-acetylcysteine (NAC) and fructose-1,6-bisphosphate (FBP). The complete Fenton system increased the AOPPs levels and both NAC and FBP were capable of inhibiting the formation of Fenton reaction-induced AOPPs. These data provide a new hypothesis about another pathway of AOPPs formation, as well as report that NAC and FBP may be good candidates to neutralize pro-inflammatory and pro-oxidant effects of AOPPs in several diseases.

Citing Articles

Are Advanced Oxidation Protein Products (AOPPs) Levels Altered in Neuropsychiatric Disorders? An Integrative Review.

de Brum G, Bochi G Mol Neurobiol. 2024; 61(11):9043-9059.

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Advanced Oxidative Protein Products Role in Multiple Sclerosis: a Systematic Review and Meta-analysis.

Rodrigues P, Bochi G, Trevisan G Mol Neurobiol. 2021; 58(11):5724-5742.

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Redox Challenge in a Cultured Temperate Marine Species During Low Temperature and Temperature Recovery.

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Assessment of Antimicrobial and Antioxidant Activities of Nepeta trachonitica: Analysis of Its Phenolic Compounds Using HPLC-MS/MS.

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Reactive oxygen species and antioxidant defense in human gastrointestinal diseases.

Patlevic P, Vaskova J, Svorc Jr P, Vasko L, Svorc P Integr Med Res. 2017; 5(4):250-258.

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