Fenton Reaction-Generated Advanced Oxidation Protein Products Induces Inflammation in Human Embryonic Kidney Cells

Overview

Journal Inflammation

Specialties Allergy & Immunology
Pathology

Date 2016 May 6

PMID 27145783

Citations 7

Authors

Guilherme Vargas Bochi

Vanessa Dorneles Torbitz

Roberto Christ Vianna Santos

Monica Cubillos-Rojas

Jose Luis Rosa Lopez

Anna Maria Siebel

Patricia Gomes

Jarbas Rodrigues de Oliveira

Rafael Noal Moresco

Affiliations

Soon will be listed here.

Abstract

Fenton reaction is a new mechanism able to generate advanced oxidation protein products (AOPPs) by exposing the human serum albumin to the Fenton system. Here, we characterized the effects of Fenton reaction-generated advanced oxidation protein products (AOPP-FR) on the gene transcription of the nuclear factor-κB (NF-κB), cyclooxygenase-2 (COX-2), and interleukin-6 (IL-6) in human embryonic kidney cells (HEK 293). To investigate the effects of AOPP-FR and AOPP-HOCl on transcription of inflammatory genes, the NF-κB, COX-2, and IL-6 luciferase promoter activities were analyzed. AOPP-FR and AOPP-HOCl were able to induce the activation of the gene transcription of NF-κB, COX-2, and IL-6 in HEK 293 cells. However, the effects of AOPP-FR were significantly higher than the effects of AOPP-HOCl in relation to COX-2 and IL-6. AOPP-FR induces the activation of the gene transcription of NF-κB, COX-2, and IL-6 and may represent a novel pathogenic mediator of inflammation in kidney.

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