Effects of Bioactive Lipids and Lipoproteins on Bone

Overview

Journal Trends Endocrinol Metab

Specialty Endocrinology

Date 2013 Nov 5

PMID 24183940

Citations 37

Authors

Yin Tintut

Linda L Demer

Affiliations

Soon will be listed here.

Abstract

Although epidemiological studies from the past two decades show a link between atherosclerotic vascular disease and bone loss, that is independent of age, the mechanism is still unclear. This review focuses on evidence that suggests a role for atherogenic lipids and lipoproteins in the pathogenesis of bone loss, including direct effects of these bioactive lipids/lipoproteins on bone cells, inhibiting osteoblastic differentiation and promoting osteoclastic differentiation. It also addresses recent evidence that suggests that bioactive lipids blunt the effects of bone anabolic agents such as teriparatide and bone morphogenetic proteins. Systemic and intracellular oxidant stress and inflammation are implicated in mediating the effects of bioactive lipids/lipoproteins.

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