Control of Osteoblast Function and Regulation of Bone Mass

Overview

Journal Nature

Specialty Science

Date 2003 May 16

PMID 12748654

Citations 468

Authors

Shun-ichi Harada

Gideon A Rodan

Affiliations

Soon will be listed here.

Abstract

The skeleton is an efficient 'servo' (feedback-controlled/steady-state) system that continuously integrates signals and responses which sustain its functions of delivering calcium while maintaining strength. In many individuals, bone mass homeostasis starts failing in midlife, leading to bone loss, osteoporosis and debilitating fractures. Recent advances, spearheaded by genetic information, offer the opportunity to stop or reverse this downhill course.

Citing Articles

Roles of lncRNA in the crosstalk between osteogenesis and angiogenesis in the bone microenvironment.

Zhang S, Guo J, He Y, Su Z, Feng Y, Zhang L J Zhejiang Univ Sci B. 2025; 26(2):107-123.

PMID: 40015932 PMC: 11867785. DOI: 10.1631/jzus.B2300607.

Hyperbaric Oxygen Therapy for the Treatment of Bone-Related Diseases.

Feng J, Zhu C, Zou J, Zhang L Int J Mol Sci. 2025; 26(3).

PMID: 39940834 PMC: 11817436. DOI: 10.3390/ijms26031067.

Single-cell RNA sequencing revealed PPARG promoted osteosarcoma progression: based on osteoclast proliferation.

Sun L, Zhang J, Xiahou Z, Zhao Z, Liang Y Front Immunol. 2025; 15:1506225.

PMID: 39936154 PMC: 11810940. DOI: 10.3389/fimmu.2024.1506225.

FGFR antagonists restore defective mandibular bone repair in a mouse model of osteochondrodysplasia.

Morice A, de La Seigliere A, Kany A, Khonsari R, Bensidhoum M, Puig-Lombardi M Bone Res. 2025; 13(1):12.

PMID: 39837840 PMC: 11751307. DOI: 10.1038/s41413-024-00385-x.

Exhaled breath metabolites reveal postmenopausal gut-bone cross-talk and non-invasive markers for osteoporosis.

Sukul P, Fischer D, Broderius C, Grzegorzewski S, Rahn A, Mittlmeier T Commun Med (Lond). 2024; 4(1):279.

PMID: 39732987 PMC: 11682404. DOI: 10.1038/s43856-024-00723-4.