Conduits of Life's Spark: a Perspective on Ion Channel Research Since the Birth of Neuron

Overview

Journal Neuron

Publisher Cell Press

Specialty Neurology

Date 2013 Nov 5

PMID 24183018

Citations 26

Authors

Ehud Y Isacoff

Lily Y Jan

Daniel L Minor Jr

Affiliations

Soon will be listed here.

Abstract

Heartbeats, muscle twitches, and lightning-fast thoughts are all manifestations of bioelectricity and rely on the activity of a class of membrane proteins known as ion channels. The basic function of an ion channel can be distilled into, "The hole opens. Ions go through. The hole closes." Studies of the fundamental mechanisms by which this process happens and the consequences of such activity in the setting of excitable cells remains the central focus of much of the field. One might wonder after so many years of detailed poking at such a seemingly simple process, is there anything left to learn?

Citing Articles

Distinct mechanisms of inhibition of Kv2 potassium channels by tetraethylammonium and RY785.

Zhang S, Stix R, Orabi E, Bernhardt N, Faraldo-Gomez J bioRxiv. 2024; .

PMID: 39372771 PMC: 11451595. DOI: 10.1101/2024.07.25.605170.

Biomimetic Neuromorphic Sensory System via Electrolyte Gated Transistors.

Li S, Gao L, Liu C, Guo H, Yu J Sensors (Basel). 2024; 24(15).

PMID: 39123962 PMC: 11314768. DOI: 10.3390/s24154915.

EMC chaperone-Ca structure reveals an ion channel assembly intermediate.

Chen Z, Mondal A, Abderemane-Ali F, Jang S, Niranjan S, Montano J Nature. 2023; 619(7969):410-419.

PMID: 37196677 PMC: 10896479. DOI: 10.1038/s41586-023-06175-5.

Potassium Ion Channels in Malignant Central Nervous System Cancers.

Boyle Y, Johns T, Fletcher E Cancers (Basel). 2022; 14(19).

PMID: 36230692 PMC: 9563970. DOI: 10.3390/cancers14194767.

Quaternary structure independent folding of voltage-gated ion channel pore domain subunits.

Arrigoni C, Lolicato M, Shaya D, Rohaim A, Findeisen F, Fong L Nat Struct Mol Biol. 2022; 29(6):537-548.

PMID: 35655098 PMC: 9809158. DOI: 10.1038/s41594-022-00775-x.

References

Deneris E, Connolly J, Boulter J, Wada E, Wada K, Swanson L . Primary structure and expression of beta 2: a novel subunit of neuronal nicotinic acetylcholine receptors. Neuron. 1988; 1(1):45-54. DOI: 10.1016/0896-6273(88)90208-5. View

Ramsey I, Moran M, Chong J, Clapham D . A voltage-gated proton-selective channel lacking the pore domain. Nature. 2006; 440(7088):1213-6. PMC: 4084761. DOI: 10.1038/nature04700. View

Klint J, Senff S, Rupasinghe D, Er S, Herzig V, Nicholson G . Spider-venom peptides that target voltage-gated sodium channels: pharmacological tools and potential therapeutic leads. Toxicon. 2012; 60(4):478-91. DOI: 10.1016/j.toxicon.2012.04.337. View

Liu Y, Holmgren M, Jurman M, Yellen G . Gated access to the pore of a voltage-dependent K+ channel. Neuron. 1997; 19(1):175-84. DOI: 10.1016/s0896-6273(00)80357-8. View

Miwa J, Freedman R, Lester H . Neural systems governed by nicotinic acetylcholine receptors: emerging hypotheses. Neuron. 2011; 70(1):20-33. PMC: 4418790. DOI: 10.1016/j.neuron.2011.03.014. View

Minor Jr D, Findeisen F . Progress in the structural understanding of voltage-gated calcium channel (CaV) function and modulation. Channels (Austin). 2010; 4(6):459-74. PMC: 3018750. DOI: 10.4161/chan.4.6.12867. View

Dancourt J, Barlowe C . Protein sorting receptors in the early secretory pathway. Annu Rev Biochem. 2010; 79:777-802. DOI: 10.1146/annurev-biochem-061608-091319. View

Dong C, Nichols C, Guo J, Huang W, Lambert N, Wu G . A triple arg motif mediates α(2B)-adrenergic receptor interaction with Sec24C/D and export. Traffic. 2012; 13(6):857-68. PMC: 3350609. DOI: 10.1111/j.1600-0854.2012.01351.x. View

Chakrapani S, Sompornpisut P, Intharathep P, Roux B, Perozo E . The activated state of a sodium channel voltage sensor in a membrane environment. Proc Natl Acad Sci U S A. 2010; 107(12):5435-40. PMC: 2851821. DOI: 10.1073/pnas.0914109107. View

10.

Xia H, Hornby Z, Malenka R . An ER retention signal explains differences in surface expression of NMDA and AMPA receptor subunits. Neuropharmacology. 2001; 41(6):714-23. DOI: 10.1016/s0028-3908(01)00103-4. View

11.

Miller C, Stahl N, Barrol M . A thermodynamic analysis of monovalent cation permeation through a K(+)-selective ion channel. Neuron. 1988; 1(2):159-64. DOI: 10.1016/0896-6273(88)90200-0. View

12.

Eshaq R, Stahl L, Stone 2nd R, Smith S, Robinson L, Leidenheimer N . GABA acts as a ligand chaperone in the early secretory pathway to promote cell surface expression of GABAA receptors. Brain Res. 2010; 1346:1-13. PMC: 2941995. DOI: 10.1016/j.brainres.2010.05.030. View

13.

Siegel R . The mRNAs encoding GABAA/benzodiazepine receptor subunits are localized in different cell populations of the bovine cerebellum. Neuron. 1988; 1(7):579-84. DOI: 10.1016/0896-6273(88)90107-9. View

14.

Li M, Jan Y, Jan L . Specification of subunit assembly by the hydrophilic amino-terminal domain of the Shaker potassium channel. Science. 1992; 257(5074):1225-30. DOI: 10.1126/science.1519059. View

15.

Kumar J, Schuck P, Mayer M . Structure and assembly mechanism for heteromeric kainate receptors. Neuron. 2011; 71(2):319-31. PMC: 3145919. DOI: 10.1016/j.neuron.2011.05.038. View

16.

Gofman Y, Shats S, Attali B, Haliloglu T, Ben-Tal N . How does KCNE1 regulate the Kv7.1 potassium channel? Model-structure, mutations, and dynamics of the Kv7.1-KCNE1 complex. Structure. 2012; 20(8):1343-52. DOI: 10.1016/j.str.2012.05.016. View

17.

Catterall W . Molecular properties of voltage-sensitive sodium channels. Annu Rev Biochem. 1986; 55:953-85. DOI: 10.1146/annurev.bi.55.070186.004513. View

18.

Liman E, Hess P, Weaver F, Koren G . Voltage-sensing residues in the S4 region of a mammalian K+ channel. Nature. 1991; 353(6346):752-6. DOI: 10.1038/353752a0. View

19.

Gill M, Kato A, Roberts M, Yu H, Wang H, Tomita S . Cornichon-2 modulates AMPA receptor-transmembrane AMPA receptor regulatory protein assembly to dictate gating and pharmacology. J Neurosci. 2011; 31(18):6928-38. PMC: 4562416. DOI: 10.1523/JNEUROSCI.6271-10.2011. View

20.

Sauguet L, Poitevin F, Murail S, Van Renterghem C, Moraga-Cid G, Malherbe L . Structural basis for ion permeation mechanism in pentameric ligand-gated ion channels. EMBO J. 2013; 32(5):728-41. PMC: 3590989. DOI: 10.1038/emboj.2013.17. View