Multi-channel Medical Device for Time Domain Functional Near Infrared Spectroscopy Based on Wavelength Space Multiplexing

Overview

Journal Biomed Opt Express

Specialty Radiology

Date 2013 Oct 25

PMID 24156079

Citations 23

Authors

Rebecca Re

Davide Contini

Massimo Turola

Lorenzo Spinelli

Lucia Zucchelli

Matteo Caffini

Rinaldo Cubeddu

Alessandro Torricelli

Affiliations

Soon will be listed here.

Abstract

We have designed a compact dual wavelength (687 nm, 826 nm) multi-channel (16 sources, 8 detectors) medical device for muscle and brain imaging based on time domain functional near infrared spectroscopy. The system employs the wavelength space multiplexing approach to reduce wavelength cross-talk and increase signal-to-noise ratio. System performances have been tested on homogeneous and heterogeneous tissue phantoms following specifically designed protocols for photon migration instruments. Preliminary in vivo measurements have been performed to validate the instrument capability to monitor hemodynamic parameters changes in the arm muscle during arterial occlusion and in the adult head during a motor task experiment.

Citing Articles

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References

Wolf M, Ferrari M, Quaresima V . Progress of near-infrared spectroscopy and topography for brain and muscle clinical applications. J Biomed Opt. 2008; 12(6):062104. DOI: 10.1117/1.2804899. View

Ye J, Tak S, Jang K, Jung J, Jang J . NIRS-SPM: statistical parametric mapping for near-infrared spectroscopy. Neuroimage. 2008; 44(2):428-47. DOI: 10.1016/j.neuroimage.2008.08.036. View

Selb J, Stott J, Franceschini M, Sorensen A, Boas D . Improved sensitivity to cerebral hemodynamics during brain activation with a time-gated optical system: analytical model and experimental validation. J Biomed Opt. 2005; 10(1):11013. DOI: 10.1117/1.1852553. View

Spinelli L, Martelli F, Farina A, Pifferi A, Torricelli A, Cubeddu R . Calibration of scattering and absorption properties of a liquid diffusive medium at NIR wavelengths. Time-resolved method. Opt Express. 2009; 15(11):6589-604. DOI: 10.1364/oe.15.006589. View

Ferrari M, Quaresima V . A brief review on the history of human functional near-infrared spectroscopy (fNIRS) development and fields of application. Neuroimage. 2012; 63(2):921-35. DOI: 10.1016/j.neuroimage.2012.03.049. View

Martelli F, Pifferi A, Contini D, Spinelli L, Torricelli A, Wabnitz H . Phantoms for diffuse optical imaging based on totally absorbing objects, part 1: Basic concepts. J Biomed Opt. 2013; 18(6):066014. PMC: 4023647. DOI: 10.1117/1.JBO.18.6.066014. View

Kacprzak M, Liebert A, Staszkiewicz W, Gabrusiewicz A, Sawosz P, Madycki G . Application of a time-resolved optical brain imager for monitoring cerebral oxygenation during carotid surgery. J Biomed Opt. 2012; 17(1):016002. DOI: 10.1117/1.JBO.17.1.016002. View

Jelzow A, Wabnitz H, Obrig H, Macdonald R, Steinbrink J . Separation of indocyanine green boluses in the human brain and scalp based on time-resolved in-vivo fluorescence measurements. J Biomed Opt. 2012; 17(5):057003. DOI: 10.1117/1.JBO.17.5.057003. View

Re R, Contini D, Caffini M, Cubeddu R, Spinelli L, Torricelli A . A compact time-resolved system for near infrared spectroscopy based on wavelength space multiplexing. Rev Sci Instrum. 2010; 81(11):113101. DOI: 10.1063/1.3495957. View

10.

Del Bianco S, Martelli F, Cignini F, Zaccanti G, Pifferi A, Torricelli A . Liquid phantom for investigating light propagation through layered diffusive media. Opt Express. 2009; 12(10):2102-11. DOI: 10.1364/opex.12.002102. View

11.

Pifferi A, Torricelli A, Bassi A, Taroni P, Cubeddu R, Wabnitz H . Performance assessment of photon migration instruments: the MEDPHOT protocol. Appl Opt. 2005; 44(11):2104-14. DOI: 10.1364/ao.44.002104. View

12.

Contini D, Martelli F, Zaccanti G . Photon migration through a turbid slab described by a model based on diffusion approximation. I. Theory. Appl Opt. 1997; 36(19):4587-99. DOI: 10.1364/ao.36.004587. View

13.

Gibson A, Austin T, Everdell N, Schweiger M, Arridge S, Meek J . Three-dimensional whole-head optical tomography of passive motor evoked responses in the neonate. Neuroimage. 2005; 30(2):521-8. DOI: 10.1016/j.neuroimage.2005.08.059. View

14.

Selb J, Joseph D, Boas D . Time-gated optical system for depth-resolved functional brain imaging. J Biomed Opt. 2006; 11(4):044008. DOI: 10.1117/1.2337320. View

15.

Kacprzak M, Liebert A, Sawosz P, Zolek N, Maniewski R . Time-resolved optical imager for assessment of cerebral oxygenation. J Biomed Opt. 2007; 12(3):034019. DOI: 10.1117/1.2743964. View

16.

Contini D, Torricelli A, Pifferi A, Spinelli L, Paglia F, Cubeddu R . Multi-channel time-resolved system for functional near infrared spectroscopy. Opt Express. 2009; 14(12):5418-32. DOI: 10.1364/oe.14.005418. View

17.

Hebden J, Gibson A, Austin T, Yusof R, Everdell N, Delpy D . Imaging changes in blood volume and oxygenation in the newborn infant brain using three-dimensional optical tomography. Phys Med Biol. 2004; 49(7):1117-30. DOI: 10.1088/0031-9155/49/7/003. View

18.

Liebert A, Sawosz P, Milej D, Kacprzak M, Weigl W, Botwicz M . Assessment of inflow and washout of indocyanine green in the adult human brain by monitoring of diffuse reflectance at large source-detector separation. J Biomed Opt. 2011; 16(4):046011. DOI: 10.1117/1.3574018. View

19.

Torricelli A, Contini D, Pifferi A, Caffini M, Re R, Zucchelli L . Time domain functional NIRS imaging for human brain mapping. Neuroimage. 2013; 85 Pt 1:28-50. DOI: 10.1016/j.neuroimage.2013.05.106. View

20.

Kirilina E, Jelzow A, Heine A, Niessing M, Wabnitz H, Bruhl R . The physiological origin of task-evoked systemic artefacts in functional near infrared spectroscopy. Neuroimage. 2012; 61(1):70-81. PMC: 3348501. DOI: 10.1016/j.neuroimage.2012.02.074. View