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The Potential Role of FNIRS in Evaluating Levels of Consciousness

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Specialty Neurology
Date 2021 Jul 26
PMID 34305558
Citations 16
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Abstract

Over the last few decades, neuroimaging techniques have transformed our understanding of the brain and the effect of neurological conditions on brain function. More recently, light-based modalities such as functional near-infrared spectroscopy have gained popularity as tools to study brain function at the bedside. A recent application is to assess residual awareness in patients with disorders of consciousness, as some patients retain awareness albeit lacking all behavioural response to commands. Functional near-infrared spectroscopy can play a vital role in identifying these patients by assessing command-driven brain activity. The goal of this review is to summarise the studies reported on this topic, to discuss the technical and ethical challenges of working with patients with disorders of consciousness, and to outline promising future directions in this field.

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References
1.
Molteni E, Contini D, Caffini M, Baselli G, Spinelli L, Cubeddu R . Load-dependent brain activation assessed by time-domain functional near-infrared spectroscopy during a working memory task with graded levels of difficulty. J Biomed Opt. 2012; 17(5):056005. DOI: 10.1117/1.JBO.17.5.056005. View

2.
Abdalmalak A, Milej D, Diop M, Shokouhi M, Naci L, Owen A . Can time-resolved NIRS provide the sensitivity to detect brain activity during motor imagery consistently?. Biomed Opt Express. 2017; 8(4):2162-2172. PMC: 5516814. DOI: 10.1364/BOE.8.002162. View

3.
Giacino J, Ashwal S, Childs N, Cranford R, Jennett B, Katz D . The minimally conscious state: definition and diagnostic criteria. Neurology. 2002; 58(3):349-53. DOI: 10.1212/wnl.58.3.349. View

4.
Marino S, Bonanno L, Ciurleo R, Baglieri A, Morabito R, Guerrera S . Functional Evaluation of Awareness in Vegetative and Minimally Conscious State. Open Neuroimag J. 2017; 11:17-25. PMC: 5427708. DOI: 10.2174/1874440001711010017. View

5.
West K, Zuppichini M, Turner M, Sivakolundu D, Zhao Y, Abdelkarim D . BOLD hemodynamic response function changes significantly with healthy aging. Neuroimage. 2018; 188:198-207. PMC: 6450381. DOI: 10.1016/j.neuroimage.2018.12.012. View