Expression and Regulation of Intergenic Long Noncoding RNAs During T Cell Development and Differentiation

Overview

Journal Nat Immunol

Date 2013 Sep 24

PMID 24056746

Citations 242

Authors

Gangqing Hu

Qingsong Tang

Suveena Sharma

Fang Yu

Thelma M Escobar

Stefan A Muljo

Jinfang Zhu

Keji Zhao

Affiliations

Soon will be listed here.

Abstract

Although intergenic long noncoding RNAs (lincRNAs) have been linked to gene regulation in various tissues, little is known about lincRNA transcriptomes in the T cell lineages. Here we identified 1,524 lincRNA clusters in 42 T cell samples, from early T cell progenitors to terminally differentiated helper T cell subsets. Our analysis revealed highly dynamic and cell-specific expression patterns for lincRNAs during T cell differentiation. These lincRNAs were located in genomic regions enriched for genes that encode proteins with immunoregulatory functions. Many were bound and regulated by the key transcription factors T-bet, GATA-3, STAT4 and STAT6. We found that the lincRNA LincR-Ccr2-5'AS, together with GATA-3, was an essential component of a regulatory circuit in gene expression specific to the TH2 subset of helper T cells and was important for the migration of TH2 cells.

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