Thelma M Escobar
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Explore the profile of Thelma M Escobar including associated specialties, affiliations and a list of published articles.
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12
Citations
812
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Recent Articles
1.
Cruz P, Pena-Lopez D, Figueroa D, Riobo I, Benedetti V, Saavedra F, et al.
Int J Mol Sci
. 2024 Oct;
25(19).
PMID: 39409021
Genome instability relies on preserving the chromatin structure, with any histone imbalances threating DNA integrity. Histone synthesis occurs in the cytoplasm, followed by a maturation process before their nuclear translocation....
2.
Escobar T, Yu J, Liu S, Lucero K, Vasilyev N, Nudler E, et al.
Sci Adv
. 2022 Apr;
8(17):eabm3945.
PMID: 35476441
The epigenetic process safeguards cell identity during cell division through the inheritance of appropriate gene expression profiles. We demonstrated previously that parental nucleosomes are inherited by the same chromatin domains...
3.
Singh A, Dashynam M, Chim B, Escobar T, Liu X, Hu X, et al.
Sci Rep
. 2021 Jun;
11(1):11498.
PMID: 34075120
MicroRNA miR-155 is an important regulatory molecule in the immune system and is highly expressed and functional in Th17 cells, a subset of CD4 T helper cells which are key...
4.
Escobar T, Loyola A, Reinberg D
Nat Rev Genet
. 2021 Jan;
22(6):379-392.
PMID: 33500558
Gene expression programmes conferring cellular identity are achieved through the organization of chromatin structures that either facilitate or impede transcription. Among the key determinants of chromatin organization are the histone...
5.
Singh A, Dashnyam M, Chim B, Escobar T, Dulcey A, Hu X, et al.
Sci Rep
. 2020 Mar;
10(1):3766.
PMID: 32111885
Th17 cells are critical drivers of autoimmune diseases and immunopathology. There is an unmet need to develop therapies targeting pathogenic Th17 cells for the treatment of autoimmune disorders. Here, we...
6.
Escobar T, Oksuz O, Saldana-Meyer R, Descostes N, Bonasio R, Reinberg D
Cell
. 2019 Nov;
179(4):953-963.e11.
PMID: 31675501
Chromatin domains and their associated structures must be faithfully inherited through cellular division to maintain cellular identity. However, accessing the localized strategies preserving chromatin domain inheritance, specifically the transfer of...
7.
Ji Y, Fioravanti J, Zhu W, Wang H, Wu T, Hu J, et al.
Nat Commun
. 2019 May;
10(1):2157.
PMID: 31089138
T cell senescence and exhaustion are major barriers to successful cancer immunotherapy. Here we show that miR-155 increases CD8 T cell antitumor function by restraining T cell senescence and functional...
8.
Bhairavabhotla R, Kim Y, Glass D, Escobar T, Patel M, Zahr R, et al.
Hum Immunol
. 2015 Dec;
77(2):201-13.
PMID: 26686412
The major goal of this study was to perform an in depth characterization of the "gene signature" of human FoxP3(+) T regulatory cells (Tregs). Highly purified Tregs and T conventional...
9.
Campos E, Smits A, Kang Y, Landry S, Escobar T, Nayak S, et al.
Mol Cell
. 2015 Nov;
60(4):697-709.
PMID: 26527279
Despite minimal disparity at the sequence level, mammalian H3 variants bind to distinct sets of polypeptides. Although histone H3.1 predominates in cycling cells, our knowledge of the soluble complexes that...
10.
Escobar T, Kanellopoulou C, Kugler D, Kilaru G, Nguyen C, Nagarajan V, et al.
Immunity
. 2014 May;
40(6):865-79.
PMID: 24856900
Specification of the T helper 17 (Th17) cell lineage requires a well-defined set of transcription factors, but how these integrate with posttranscriptional and epigenetic programs to regulate gene expression is...