Selective Cytotoxicity, Inhibition of Cell Cycle Progression, and Induction of Apoptosis in Human Breast Cancer Cells by Sesquiterpenoids from Inula Lineariifolia Turcz

Overview

Journal Eur J Med Chem

Specialty Chemistry

Date 2013 Sep 19

PMID 24044895

Citations 13

Authors

Jiang-Jiang Qin

Hui-Zi Jin

Ying Huang

Shou-De Zhang

Lei Shan

Sukesh Voruganti

Subhasree Nag

Wei Wang

Wei-Dong Zhang

Ruiwen Zhang

Affiliations

Soon will be listed here.

Abstract

Four new sesquiterpenoid dimers (lineariifolianoids E-H, 1-4), five new sesquiterpenoids (5-9), and seven known sesquiterpenoids (10-16) were isolated from the aerial parts of Inula lineariifolia Turcz. Their structures were determined by spectroscopic data analysis and X-ray diffraction studies. The compounds were then evaluated for their in vitro cytotoxicity against two human breast cancer cell lines (MCF-7 and MDA-MB-231) and one normal breast cell line (MCF-10A). Lineariifolianoid E (1) showed IC50 values of 1.56 μM and 2.75 μM against MCF-7 and MDA-MB-231, respectively. However, lineariifolianoid E demonstrated low toxicity to MCF-10A cells, which indicated a selective cytotoxicity for tumor cells. Further studies also presented that lineariifolianoid E had significant, dose-dependent effects on cell cycle progression and apoptosis in breast cancer cells.

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