Japonicones A-D, Bioactive Dimeric Sesquiterpenes from Inula Japonica Thunb

Overview

Journal Bioorg Med Chem Lett

Specialty Biochemistry

Date 2009 Jan 2

PMID 19117757

Citations 17

Authors

Jiang Jiang Qin

Hui Zi Jin

Jian Jun Fu

Xiao Jia Hu

Yan Wang

Shi Kai Yan

Wei Dong Zhang

Affiliations

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Abstract

Four new dimeric sesquiterpene lactones japonicones A-D (1-4), comprised by eudesmane and guaiane sesquiterpenes, were isolated from the aerial part of Inula japonica Thunb. The structures and stereochemistry of 1-4 were elucidated by use of 2D NMR spectroscopic techniques, X-ray crystallography and modified Mosher method. Japonicone A (1) showed the most potent cytotoxicities against four tumor cell lines, A549, LOVO, CEM and MDA-MB-435.

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