Metabolic Changes in Psoriatic Skin Under Topical Corticosteroid Treatment

Overview

Journal BMC Dermatol

Publisher Biomed Central

Specialty Dermatology

Date 2013 Aug 16

PMID 23945194

Citations 23

Authors

Beathe Sitter

Margareta Karin Johnsson

Jostein Halgunset

Tone Frost Bathen

Affiliations

Soon will be listed here.

Abstract

Background: MR spectroscopy of intact biopsies can provide a metabolic snapshot of the investigated tissue. The aim of the present study was to explore the metabolic pattern of uninvolved skin, psoriatic skin and corticosteroid treated psoriatic skin.

Methods: The three types of skin biopsy samples were excised from patients with psoriasis (N = 10). Lesions were evaluated clinically, and tissue biopsies were excised and analyzed by one-dimensional 1H MR spectroscopy. Relative levels were calculated for nine tissue metabolites. Subsequently, relative amounts of epidermis, dermis and subcutaneous tissue were scored by histopathological evaluation of HES stained sections.

Results: Seven out of 10 patients experienced at least 40% reduction in clinical score after corticosteroid treatment. Tissue biopsies from psoriatic skin contained lower levels of the metabolites myo-inositol and glucose, and higher levels of choline and taurine compared to uninvolved skin. In corticosteroid treated psoriatic skin, tissue levels of glucose, myo-inositol, GPC and glycine were increased, whereas choline was reduced, in patients with good therapeutic effect. These tissue levels are becoming more similar to metabolite levels in uninvolved skin.

Conclusion: This MR method demonstrates that metabolism in psoriatic skin becomes similar to that of uninvolved skin after effective corticosteroid treatment. MR profiling of skin lesions reflect metabolic alterations related to pathogenesis and treatment effects.

Citing Articles

Psoriasis immunometabolism: progress on metabolic biomarkers and targeted therapy.

Sarandi E, Krueger-Krasagakis S, Tsoukalas D, Sidiropoulou P, Evangelou G, Sifaki M Front Mol Biosci. 2023; 10:1201912.

PMID: 37405259 PMC: 10317015. DOI: 10.3389/fmolb.2023.1201912.

Acute and chronic inflammation alter immunometabolism in a cutaneous delayed-type hypersensitivity reaction (DTHR) mouse model.

Zizmare L, Mehling R, Gonzalez-Menendez I, Lonati C, Quintanilla-Martinez L, Pichler B Commun Biol. 2022; 5(1):1250.

PMID: 36380134 PMC: 9666528. DOI: 10.1038/s42003-022-04179-x.

Metabolomic Differences between the Skin and Blood Sera of Atopic Dermatitis and Psoriasis.

Ilves L, Ottas A, Kaldvee B, Abram K, Soomets U, Zilmer M Int J Mol Sci. 2022; 23(21).

PMID: 36361789 PMC: 9658722. DOI: 10.3390/ijms232113001.

Association of the characteristics of the blood metabolome and gut microbiome with the outcome of methotrexate therapy in psoriasis.

Qiu Q, Deng J, Deng H, Yao D, Yan Y, Ye S Front Immunol. 2022; 13:937539.

PMID: 36159864 PMC: 9491226. DOI: 10.3389/fimmu.2022.937539.

An Overview of the Latest Metabolomics Studies on Atopic Eczema with New Directions for Study.

Afghani J, Traidl-Hoffmann C, Schmitt-Kopplin P, Reiger M, Mueller C Int J Mol Sci. 2022; 23(15).

PMID: 35955924 PMC: 9368995. DOI: 10.3390/ijms23158791.

References

Sitter B, Lundgren S, Bathen T, Halgunset J, Fjosne H, Gribbestad I . Comparison of HR MAS MR spectroscopic profiles of breast cancer tissue with clinical parameters. NMR Biomed. 2005; 19(1):30-40. DOI: 10.1002/nbm.992. View

Bathen T, Sitter B, Sjobakk T, Tessem M, Gribbestad I . Magnetic resonance metabolomics of intact tissue: a biotechnological tool in cancer diagnostics and treatment evaluation. Cancer Res. 2010; 70(17):6692-6. DOI: 10.1158/0008-5472.CAN-10-0437. View

Gottlieb A, Dann F . Comorbidities in patients with psoriasis. Am J Med. 2009; 122(12):1150.e1-9. DOI: 10.1016/j.amjmed.2009.06.021. View

Kim Y, Orenberg E, Faull K, Jardetzky O . 1H NMR spectroscopy: an approach to evaluation of diseased skin in vivo. J Invest Dermatol. 1989; 92(2):210-6. DOI: 10.1111/1523-1747.ep12276738. View

Borgan E, Sitter B, Lingjaerde O, Johnsen H, Lundgren S, Bathen T . Merging transcriptomics and metabolomics--advances in breast cancer profiling. BMC Cancer. 2010; 10:628. PMC: 2996395. DOI: 10.1186/1471-2407-10-628. View

Martinez-Bisbal M, Marti-Bonmati L, Piquer J, Revert A, Ferrer P, Llacer J . 1H and 13C HR-MAS spectroscopy of intact biopsy samples ex vivo and in vivo 1H MRS study of human high grade gliomas. NMR Biomed. 2004; 17(4):191-205. DOI: 10.1002/nbm.888. View

Reich K, Bewley A . What is new in topical therapy for psoriasis?. J Eur Acad Dermatol Venereol. 2011; 25 Suppl 4:15-20. DOI: 10.1111/j.1468-3083.2011.04061.x. View

Sitter B, Sonnewald U, Spraul M, Fjosne H, Gribbestad I . High-resolution magic angle spinning MRS of breast cancer tissue. NMR Biomed. 2002; 15(5):327-37. DOI: 10.1002/nbm.775. View

Sitter B, Bathen T, Singstad T, Fjosne H, Lundgren S, Halgunset J . Quantification of metabolites in breast cancer patients with different clinical prognosis using HR MAS MR spectroscopy. NMR Biomed. 2010; 23(4):424-31. DOI: 10.1002/nbm.1478. View

10.

Hughes J, Rustin M . Corticosteroids. Clin Dermatol. 1997; 15(5):715-21. DOI: 10.1016/s0738-081x(97)00020-5. View

11.

Weibel E, KISTLER G, Scherle W . Practical stereological methods for morphometric cytology. J Cell Biol. 1966; 30(1):23-38. PMC: 2106982. DOI: 10.1083/jcb.30.1.23. View

12.

Bowes J, Barton A . The genetics of psoriatic arthritis: lessons from genome-wide association studies. Discov Med. 2010; 10(52):177-83. View

13.

Liu Y, Krueger J, Bowcock A . Psoriasis: genetic associations and immune system changes. Genes Immun. 2006; 8(1):1-12. DOI: 10.1038/sj.gene.6364351. View

14.

van Waarde A, Elsinga P . Proliferation markers for the differential diagnosis of tumor and inflammation. Curr Pharm Des. 2008; 14(31):3326-339. DOI: 10.2174/138161208786549399. View

15.

Nestle F, Kaplan D, Barker J . Psoriasis. N Engl J Med. 2009; 361(5):496-509. DOI: 10.1056/NEJMra0804595. View

16.

Caruso R, Botti E, Sarra M, Esposito M, Stolfi C, Diluvio L . Involvement of interleukin-21 in the epidermal hyperplasia of psoriasis. Nat Med. 2009; 15(9):1013-5. DOI: 10.1038/nm.1995. View