Applications of High-resolution Magic Angle Spinning MRS in Biomedical Studies II-Human Diseases

Overview

Journal NMR Biomed

Publisher Wiley

Date 2017 Sep 16

PMID 28915318

Citations 10

Authors

Christopher Dietz

Felix Ehret

Francesco Palmas

Lindsey A Vandergrift

Yanni Jiang

Vanessa Schmitt

Vera Dufner

Piet Habbel

Johannes Nowak

Leo L Cheng

Affiliations

Soon will be listed here.

Abstract

High-resolution magic angle spinning (HRMAS) MRS is a powerful method for gaining insight into the physiological and pathological processes of cellular metabolism. Given its ability to obtain high-resolution spectra of non-liquid biological samples, while preserving tissue architecture for subsequent histopathological analysis, the technique has become invaluable for biochemical and biomedical studies. Using HRMAS MRS, alterations in measured metabolites, metabolic ratios, and metabolomic profiles present the possibility to improve identification and prognostication of various diseases and decipher the metabolomic impact of drug therapies. In this review, we evaluate HRMAS MRS results on human tissue specimens from malignancies and non-localized diseases reported in the literature since the inception of the technique in 1996. We present the diverse applications of the technique in understanding pathological processes of different anatomical origins, correlations with in vivo imaging, effectiveness of therapies, and progress in the HRMAS methodology.

Citing Articles

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