Research Progress and Perspective in Metabolism and Metabolomics of Psoriasis

Overview

Journal Chin Med J (Engl)

Specialty General Medicine

Date 2020 Nov 25

PMID 33237698

Citations 8

Authors

Ni Lian

Li-Qing Shi

Zhi-Min Hao

Min Chen

Affiliations

Soon will be listed here.

Abstract

Psoriasis is considered a systemic disease associated with metabolic abnormalities, and it is important to understand the mechanisms by which metabolism affects pathophysiological processes both holistically and systematically. Metabolites are closely related to disease phenotypes, especially in systemic diseases under multifactorial modulation. The emergence of metabolomics has provided information regarding metabolite changes in lesions and circulation and deepened our understanding of the association between metabolic reprogramming and psoriasis. Metabolomics has great potential for the development of effective biomarkers for clinical diagnosis, therapeutic monitoring, prediction of the efficacy of psoriasis management, and further discovery of new metabolism-based therapeutic targets.

Citing Articles

Energy competition remodels the metabolic glucose landscape of psoriatic epidermal cells.

Liu W, Jiang J, Li Z, Xiao Y, Zhou S, Wang D Theranostics. 2024; 14(8):3339-3357.

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Development and trends in metabolomics studies in psoriasis: A bibliometric analysis of related research from 2011 to 2024.

Zhang L, Li Y, Zhang Y, Cai Y, Li L, Ying L Heliyon. 2024; 10(8):e29794.

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Signaling pathways and targeted therapies for psoriasis.

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Psoriasis immunometabolism: progress on metabolic biomarkers and targeted therapy.

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Metabolomics analysis reveals cytotoxic effects of ouabain towards psoriatic keratinocytes via impairment of glutathione metabolism.

Zhou X, Fei F, Song W, Ma H, Xu Z, Yue J Mol Genet Genomics. 2023; 298(3):567-577.

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