Asbestos and Erionite Prime and Activate the NLRP3 Inflammasome That Stimulates Autocrine Cytokine Release in Human Mesothelial Cells

Overview

Journal Part Fibre Toxicol

Publisher Biomed Central

Specialty Toxicology

Date 2013 Aug 14

PMID 23937860

Citations 48

Authors

Jedd M Hillegass

Jill M Miller

Maximilian B MacPherson

Catherine M Westbom

Mutlay Sayan

Joyce K Thompson

Sherrill L Macura

Timothy N Perkins

Stacie L Beuschel

Vlada Alexeeva

Harvey I Pass

Chad Steele

Brooke T Mossman

Arti Shukla

Affiliations

Soon will be listed here.

Abstract

Background: Pleural fibrosis and malignant mesotheliomas (MM) occur after exposures to pathogenic fibers, yet the mechanisms initiating these diseases are unclear.

Results: We document priming and activation of the NLRP3 inflammasome in human mesothelial cells by asbestos and erionite that is causally related to release of IL-1β, IL-6, IL-8, and Vascular Endothelial Growth Factor (VEGF). Transcription and release of these proteins are inhibited in vitro using Anakinra, an IL-1 receptor antagonist that reduces these cytokines in a human peritoneal MM mouse xenograft model.

Conclusions: These novel data show that asbestos-induced priming and activation of the NLRP3 inflammasome triggers an autocrine feedback loop modulated via the IL-1 receptor in mesothelial cell type targeted in pleural infection, fibrosis, and carcinogenesis.

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