Inflammasome in the Pathogenesis of Pulmonary Diseases

Overview

Journal Exp Suppl

Specialties General Medicine
Science

Date 2018 Dec 12

PMID 30536170

Citations 7

Authors

Fengying Xu

Zongmei Wen

Xueying Shi

Jie Fan

Affiliations

Soon will be listed here.

Abstract

Lung diseases are common and significant causes of illness and death around the world. Inflammasomes have emerged as an important regulator of lung diseases. The important role of IL-1 beta and IL-18 in the inflammatory response of many lung diseases has been elucidated. The cleavage to turn IL-1 beta and IL-18 from their precursors into the active forms is tightly regulated by inflammasomes. In this chapter, we structurally review current evidence of inflammasome-related components in the pathogenesis of acute and chronic lung diseases, focusing on the "inflammasome-caspase-1-IL-1 beta/IL-18" axis.

Citing Articles

Lopez Rodriguez C, Boigues Pons M, Quirant Sanchez B, Teniente Serra A, Climent Marti J, Martinez Caceres E Adv Lab Med. 2023; 1(4):20200045.

PMID: 37360616 PMC: 10197510. DOI: 10.1515/almed-2020-0045.

Lopez Rodriguez C, Boigues Pons M, Quirant Sanchez B, Teniente Serra A, Climent Marti J, Martinez Caceres E Adv Lab Med. 2023; 1(4):20200083.

PMID: 37360613 PMC: 10197769. DOI: 10.1515/almed-2020-0083.

Caspase-1 and interleukin-18 in children with post infectious bronchiolitis obliterans: a case-control study.

Sismanlar Eyuboglu T, Tana Aslan A, Ramasli Gursoy T, Pekcan S, Kose M, Hangul M Eur J Pediatr. 2022; 181(8):3093-3101.

PMID: 35705877 DOI: 10.1007/s00431-022-04528-2.

Oxidative Stress Promotes Corticosteroid Insensitivity in Asthma and COPD.

Lewis B, Ford M, Rogers L, Britt Jr R Antioxidants (Basel). 2021; 10(9).

PMID: 34572965 PMC: 8471691. DOI: 10.3390/antiox10091335.

Oxidative Imbalance as a Crucial Factor in Inflammatory Lung Diseases: Could Antioxidant Treatment Constitute a New Therapeutic Strategy?.

Victoni T, Barreto E, Lagente V, Carvalho V Oxid Med Cell Longev. 2021; 2021:6646923.

PMID: 33628371 PMC: 7889360. DOI: 10.1155/2021/6646923.

References

Schmitz N, Kurrer M, Bachmann M, Kopf M . Interleukin-1 is responsible for acute lung immunopathology but increases survival of respiratory influenza virus infection. J Virol. 2005; 79(10):6441-8. PMC: 1091664. DOI: 10.1128/JVI.79.10.6441-6448.2005. View

Wrigge H, Zinserling J, Stuber F, von Spiegel T, Hering R, Wetegrove S . Effects of mechanical ventilation on release of cytokines into systemic circulation in patients with normal pulmonary function. Anesthesiology. 2001; 93(6):1413-7. DOI: 10.1097/00000542-200012000-00012. View

Nakae S, Komiyama Y, Yokoyama H, Nambu A, Umeda M, Iwase M . IL-1 is required for allergen-specific Th2 cell activation and the development of airway hypersensitivity response. Int Immunol. 2003; 15(4):483-90. DOI: 10.1093/intimm/dxg054. View

Pereira M, Marques G, Dellama J, Zamboni D . The Nlrc4 Inflammasome Contributes to Restriction of Pulmonary Infection by Flagellated Legionella spp. that Trigger Pyroptosis. Front Microbiol. 2011; 2:33. PMC: 3109297. DOI: 10.3389/fmicb.2011.00033. View

Riteau N, Gasse P, Fauconnier L, Gombault A, Couegnat M, Fick L . Extracellular ATP is a danger signal activating P2X7 receptor in lung inflammation and fibrosis. Am J Respir Crit Care Med. 2010; 182(6):774-83. DOI: 10.1164/rccm.201003-0359OC. View

Kool M, Willart M, van Nimwegen M, Bergen I, Pouliot P, Virchow J . An unexpected role for uric acid as an inducer of T helper 2 cell immunity to inhaled antigens and inflammatory mediator of allergic asthma. Immunity. 2011; 34(4):527-40. DOI: 10.1016/j.immuni.2011.03.015. View

Idzko M, Hammad H, van Nimwegen M, Kool M, Willart M, Muskens F . Extracellular ATP triggers and maintains asthmatic airway inflammation by activating dendritic cells. Nat Med. 2007; 13(8):913-9. DOI: 10.1038/nm1617. View

Rich P, Douillet C, Mahler S, Husain S, Boucher R . Adenosine triphosphate is released during injurious mechanical ventilation and contributes to lung edema. J Trauma. 2003; 55(2):290-7. DOI: 10.1097/01.TA.0000078882.11919.AF. View

Muller T, Vieira R, Grimm M, Durk T, Cicko S, Zeiser R . A potential role for P2X7R in allergic airway inflammation in mice and humans. Am J Respir Cell Mol Biol. 2010; 44(4):456-64. DOI: 10.1165/rcmb.2010-0129OC. View

10.

Amer A, Franchi L, Kanneganti T, Body-Malapel M, Ozoren N, Brady G . Regulation of Legionella phagosome maturation and infection through flagellin and host Ipaf. J Biol Chem. 2006; 281(46):35217-23. DOI: 10.1074/jbc.M604933200. View

11.

Hornung V, Bauernfeind F, Halle A, Samstad E, Kono H, Rock K . Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization. Nat Immunol. 2008; 9(8):847-56. PMC: 2834784. DOI: 10.1038/ni.1631. View

12.

Netea M, Kullberg B, Jacobs L, Verver-Jansen T, van der Ven-Jongekrijg J, Galama J . Chlamydia pneumoniae stimulates IFN-gamma synthesis through MyD88-dependent, TLR2- and TLR4-independent induction of IL-18 release. J Immunol. 2004; 173(2):1477-82. DOI: 10.4049/jimmunol.173.2.1477. View

13.

Broide D, Lotz M, Cuomo A, Coburn D, Federman E, Wasserman S . Cytokines in symptomatic asthma airways. J Allergy Clin Immunol. 1992; 89(5):958-67. DOI: 10.1016/0091-6749(92)90218-q. View

14.

Thomas S, Chhabra S . A study on the serum levels of interleukin-1beta in bronchial asthma. J Indian Med Assoc. 2003; 101(5):282, 284, 286 passim. View

15.

Koo I, Wang C, Raghavan S, Morisaki J, Cox J, Brown E . ESX-1-dependent cytolysis in lysosome secretion and inflammasome activation during mycobacterial infection. Cell Microbiol. 2008; 10(9):1866-78. PMC: 2574867. DOI: 10.1111/j.1462-5822.2008.01177.x. View

16.

Davis G, Pfeiffer L, Hemenway D . Persistent overexpression of interleukin-1beta and tumor necrosis factor-alpha in murine silicosis. J Environ Pathol Toxicol Oncol. 1998; 17(2):99-114. View

17.

Kolb M, Margetts P, Anthony D, Pitossi F, Gauldie J . Transient expression of IL-1beta induces acute lung injury and chronic repair leading to pulmonary fibrosis. J Clin Invest. 2001; 107(12):1529-36. PMC: 200196. DOI: 10.1172/JCI12568. View

18.

Kuschner W, DAlessandro A, Wong H, Blanc P . Dose-dependent cigarette smoking-related inflammatory responses in healthy adults. Eur Respir J. 1996; 9(10):1989-94. DOI: 10.1183/09031936.96.09101989. View

19.

Wu J, Yan Z, Schwartz D, Yu J, Malik A, Hu G . Activation of NLRP3 inflammasome in alveolar macrophages contributes to mechanical stretch-induced lung inflammation and injury. J Immunol. 2013; 190(7):3590-9. PMC: 3608749. DOI: 10.4049/jimmunol.1200860. View

20.

Riha R, Yang I, Rabnott G, Tunnicliffe A, Fong K, Zimmerman P . Cytokine gene polymorphisms in idiopathic pulmonary fibrosis. Intern Med J. 2004; 34(3):126-9. DOI: 10.1111/j.1444-0903.2004.00503.x. View